Head and neck radiation and mucositis
Head and neck radiation and mucositis
复制标题
头颈部放射和粘膜炎
DOI：
--
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发表时间：
2007
影响因子：
2.1
通讯作者：
M. Chambers
中科院分区：
文献类型：
--
作者：
A. Garden;M. Chambers
综述的目的我们将回顾最近的文献，这些文献为粘膜炎的发病机制、指标和治疗提供了新的见解。最近的发现放射治疗技术包括适形治疗和调强治疗，试图尽量减少对正常组织的剂量，同时仍然提供高剂量的肿瘤目标。用于预防或治疗粘膜炎的药物通常分为三类：抗菌剂，生长因子和辐射防护剂。到目前为止，所有这三类药物在预防辐射诱导的粘膜炎方面几乎没有成功，但帕利弗明（一种角质细胞生长因子）和RK-0202（一种局部辐射保护剂）有希望，并正在研究中。头颈部肿瘤患者的治疗通常需要多模式治疗，放射治疗通常是这种方法的关键组成部分。不幸的是，治疗患者所需的剂量密集方案经常导致粘膜炎。虽然这种治疗后遗症早已被认识到，但直到最近，研究人员才清楚地确定了其发病率，并制定了量化粘膜炎及其症状的指标。尽量减少粘膜炎的努力涉及放射物理学的进步和预防或治疗粘膜炎的药理学试剂的开发。虽然迄今为止还没有药物在降低头颈部癌症患者辐射诱导的粘膜炎的发生率方面显示出显著的疗效，但目前正在测试几种药物并保持承诺。
Purpose of reviewWe will review the recent literature that has provided new insights into the pathogenesis, metrics and therapeutics of mucositis. Recent findingsRadiation techniques include conformal therapy and intensity modulated therapy that attempt to minimize dose to normal tissues while still delivering high doses to tumor targets. Drugs used to prevent or treat mucositis typically fall into three classes: antimicrobials, growth factors and radioprotectors. To date, drugs in all three categories have had little success in preventing radiation-induced mucositis, but palifermin, a keratinocyte growth factor, and RK-0202, a topical radioprotector, hold promise and are under investigation. SummaryTreatment of patients with head and neck cancers often requires multimodality therapy, and radiotherapy is often a critical component of this approach. Unfortunately, the dose intense regimens required to treat patients often results in mucositis. While this treatment sequela has long been recognized, only recently have researchers clearly identified its incidence and developed metrics to quantify mucositis and its resultant symptoms. Efforts to minimize mucositis have involved both advances in radiation physics, and the development of pharmacologic agents to prevent or treat mucositis. While no drug to date has shown significant efficacy in reducing the incidence of radiation-induced mucositis for head and neck cancer patients, several agents are currently being tested and hold promise.
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M
并发粒细胞巨噬细胞集落刺激因子对头颈癌患者放射性粘膜炎的影响：放射治疗肿瘤学组 9901 进行的双盲安慰剂对照前瞻性 III 期研究。
DOI：
10.1016/j.ijrobp.2006.09.043
发表时间：
2007
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Ryu,JaniceK;Swann,Suzanne;LeVeque,Francis;Scarantino,CharlesW;Johnson,Darlene;Chen,Allan;Fortin,Andre;Pollock,JonDavid;Kim,Harold;Ang,KianK
通讯作者：
Ang,KianK