Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging
Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging
复制标题
DOI：
10.1111/j.1524-4725.2008.34283.x
复制
发表时间：
2008-10-01
影响因子：
2.4
通讯作者：
Kim, Won-Serk
中科院分区：
文献类型：
--
作者：
Park, Byung-Soon;Jang, Kyoung Ae;Kim, Won-Serk
背景脂肪干细胞及其分泌因子在创伤愈合过程中可刺激成纤维细胞的胶原合成和迁移。皮肤老化的常规治疗，如激光和局部疗法，通过激活真皮成纤维细胞或生长因子诱导新的胶原蛋白合成。ADSCs也可用于皮肤老化的治疗。目的：探讨ADSCs治疗皮肤老化的有效性。方法：将ADSCs（1 × 10（6）个细胞，1 mL Hanks'缓冲盐溶液）和ADSCs条件培养液皮内注射于小型猪背部，分析ADSCs的分泌因子。此外，作为一个试点研究，我们尝试皮内注射纯化的自体处理的脂肪抽吸（PLA）细胞与光老化的皮肤patient.Results我们证明，脂肪干细胞产生许多有用的生长因子，增加胶原蛋白的产生在动物实验中，并逆转皮肤老化在人体试验中。结论脂肪干细胞及其分泌因子显示出应用前景的美容皮肤病学，特别是在治疗皮肤老化。
BACKGROUND Adipose-derived stem cells (ADSCs) and their secretory factors can stimulate collagen synthesis and migration of fibroblasts during the wound healing process. Conventional treatments for skin aging, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. Considering the results of our previous study, ADSCs can also be used for the treatment of skin aging.OBJECTIVE The aim was to verify the effectiveness of ADSCs for the treatment of skin aging.METHODS We analyzed secretory factors of ADSCs and intradermally injected ADSCs (1 x 10(6) cells in 1 mL of Hanks' buffered salt solution) and conditioned media of ADSCs on the back of a micropig. In addition, as a pilot study, intradermal injections of purified autologous processed lipoaspirate (PLA) cells were tried with the photoaged skin of one patient.RESULTS We demonstrated that ADSCs produce many useful growth factors, increase collagen production in animal study, and reverse skin aging in human trial.CONCLUSION ADSCs and their secretory factors show promise for application in cosmetic dermatology, especially in the treatment of skin aging.