Generation of hydrogen peroxide, superoxide anion and the hydroxyl free radical from polyphenols and active benzene metabolites: Their possible role in mutagenesis
Generation of hydrogen peroxide, superoxide anion and the hydroxyl free radical from polyphenols and active benzene metabolites: Their possible role in mutagenesis
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DOI：
10.1007/bf02257986
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发表时间：
1994-01-01
影响因子：
11
通讯作者：
Lin, Jen-Kun
中科院分区：
文献类型：
--
作者：
Lee, Shern-Fwu;Lin, Jen-Kun
Benzene is strongly suspected of being an animal and human carcinogen, but the mechanisms by which it induces tumors of lymphoid and hematopoietic organs are unknown. Production of active oxygen species from benzene metabolites (hydroquinone (HQ), catechol and 1,2,4-benzenetriol (1,2,4-BT) and related polyphenols (resorcinol, pyrogallol and phloroglucinol) are investigated. Pyrogallol and 1,2,4,-BT can produce H-2O2, O-2 and .OH simultaneously, and have powerful mutagenic potential. Resorcinol and phloroglucinol cannot produce all the active oxygen species, and show no mutagenic effects. Catechol can produce H-2O-2, but cannot produce O-2 and .OH, and has no mutagenic activity. These data strongly support the hypothesis that benzene metabolites can cause mutagenicity via the generation of oxygen radicals. Although HQ produces H-2O2 only, and less than produced by pyrogallol and 1,2,4-BT, the mutagenicity of HQ is higher. The results indicate that HQ may act via another mechanism to cause mutagenicity. In the presence of trace metal ions, the reactivity of polyphenols is increased. The biological significance of these phenomena are investigated and discussed.
