CONGENITAL MALFORMATIONS OF CENTRAL NERVOUS-SYSTEM IN SPONTANEOUS ABORTIONS
CONGENITAL MALFORMATIONS OF CENTRAL NERVOUS-SYSTEM IN SPONTANEOUS ABORTIONS
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DOI：
10.1136/jmg.13.1.9
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发表时间：
1976-01-01
影响因子：
4
通讯作者：
ALBERMAN, ED
中科院分区：
文献类型：
--
作者：
CREASY, MR;ALBERMAN, ED
一项对2620例自然流产妊娠的研究显示，3.6%的胚胎和胎儿以及3%的完整妊娠存在CNS缺陷。观察到的畸形类型随排出时的胎龄而变化，脑膨出在早期标本中占主导地位，而更典型的无脑儿和脊柱裂在晚期流产中更常见。染色体异常被发现在40%的流产与中枢神经系统的缺陷，但几乎完全局限于那些仍然在胚胎发育阶段。后者中有53%染色体异常，这与没有CNS畸形的胚胎中发现的比例相同。利用已发表的已确认妊娠的生命表，估计无脑儿、脊柱裂或相关畸形（脑积水除外）的患病率在妊娠第8周开始时为5.3%.。通过与总出生率进行比较，进一步估计其中只有24%是活产，54%是自然流产，22%是死产。
A study of 2620 pregnancies ending in spontaneous abortion revealed a CNS defect in 3.6% of embryos and fetuses, and 3% of all complete conceptuses. The type of malformation observed varied with the gestational age at expulsion, encephaloceles being predominant in earlier specimens, while more typical anencephalus and spina bifida were more common among later abortions. Chromosome abnormalities were found in 40% of abortuses with CNS defects, but were almost entirely confined to those which were still at the embryonic stage of development. 53% of the latter were chromosomally abnormal, which is the same as the proportion found among embryos without a CNS malformation. Using published life-tables of recognized pregnancies it was estimated that the prevalence of anencephalus, spina bifida, or related malformation (other than hydrocephalus), without a chromosome anomaly, is 5.3 per thousand conceptuses at the beginning of the eighth week of gestation. By comparing this with the prevalence in total births, it was further estimated that only 24% of these are born alive, with 54% aborting spontaneously and 22% being stillborn.