Feasibility of noninvasive measurement of deep brain temperature in newborn infants by multifrequency microwave radiometry
Feasibility of noninvasive measurement of deep brain temperature in newborn infants by multifrequency microwave radiometry
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DOI：
10.1109/22.884206
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发表时间：
2000-11-01
影响因子：
4.3
通讯作者：
Land, D
中科院分区：
文献类型：
--
作者：
Maruyma, K;Mizushina, S;Land, D
目前，脑深部温度测量困难阻碍了新生儿缺氧缺血后低温神经抢救治疗的临床研究。本文涉及：针对该测量问题的具体要求，提出了一种辐射计系统的设计方案，一种获取冷却头内温度分布的方法，以及使用该技术测量深部脑温度的精度估计。提出了一种工作在1 ~ 4 GHz范围内的接触式天线五频段辐射计，该辐射计可获得与实际婴儿头部冷却热模型预测的温度曲线相对应的亮度温度。利用模型拟合和蒙特卡罗技术的结合，解决了从这组亮度温度中检索温度分布及其精度估计的问题。本文的结果表明，所提出的技术是可行的，它有望提供一个很好的估计冷却婴儿头部内的温度分布，并且在脑深部结构中测量的温度的估计精度（2西格玛）优于0.8 K，这取决于所使用的估计程序。
Clinical studies of hypothermal neural rescue therapy for newborn infants who have suffered hypoxia-ischaemia are currently hindered by the difficulty in measuring deep brain temperature. This paper addresses: the specific requirements for this measurement problem, the design of a proposed radiometer system, a method for retrieving the temperature profile within the cooled head, and an estimation of the precision of the measurement of deep brain temperature using the technique, A five-frequency-band radiometer with a contact-type antenna operating within the range 1-4 GHz is proposed to obtain brightness temperatures corresponding to temperature profiles predicted by a realistic thermal model of the cooled baby head. The problems of retrieving the temperature profile from this set of brightness temperatures, and the estimation of its precision, are solved using a combination of model fitting and Monte Carlo techniques. The results of this paper show that the proposed technique is feasible, that it is expected to provide a good estimate of the temperature profile within the cooled baby-head, and that the estimated precision (2 sigma) of the temperature measured in the deep brain structures is better than 0.8 K, depending upon the estimation procedure used.