Epithelial cell-extracellular matrix interactions and stem cells in airway epithelial regeneration.
Epithelial cell-extracellular matrix interactions and stem cells in airway epithelial regeneration.
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DOI：
10.1513/pats.200801-010aw
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Birembaut, Philippe
中科院分区：
文献类型：
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作者：
Coraux, Christelle;Roux, Jacqueline;Birembaut, Philippe
在健康受试者中，呼吸道上皮形成气道和环境的连续衬里，并发挥独特的作用，作为抵御外部有害物质的屏障，保护气道免受侵害。在囊性纤维化（CF）、慢性阻塞性肺病（COPD）、慢性支气管炎或哮喘等呼吸系统疾病中，气道上皮经常发生重塑和损伤，导致其防御功能受损。上皮屏障的快速恢复对于这些患者至关重要。气道上皮的完全再生是一个复杂的现象，不仅包括上皮伤口修复，还包括上皮分化以重建完全分化良好的功能性上皮。再生意味着两个伙伴：上皮干/祖细胞和能够调节该过程的因子。在这些因素中，上皮细胞-细胞外基质（ECM）相互作用起着至关重要的作用。临时 ECM 的分泌、通过上皮受体建立的细胞-ECM 关系以及蛋白酶（主要是基质金属蛋白酶）对 ECM 的重塑不仅通过调节上皮细胞迁移和增殖来促进气道上皮修复，而且还有助于修复细胞的分化，从而导致受伤上皮的完全恢复。更好地表征驻留干细胞和再生过程的效应器是向患有传染性/炎症性呼吸道疾病的患者提出新的再生疗法的必要先决条件。
In healthy subjects, the respiratory epithelium forms a continuous lining to the airways and to the environment, and plays a unique role as a barrier against external deleterious agents to protect the airways from the insults. In respiratory diseases such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), chronic bronchitis, or asthma, the airway epithelium is frequently remodeled and injured, leading to the impairment of its defense functions. The rapid restoration of the epithelial barrier is crucial for these patients. The complete regeneration of the airway epithelium is a complex phenomenon, including not only the epithelial wound repair but also the epithelial differentiation to reconstitute a fully well differentiated and functional epithelium. The regeneration implies two partners: the epithelial stem/progenitor cells and factors able to regulate this process. Among these factors, epithelial cells-extracellular matrix (ECM) interactions play a crucial role. The secretion of a provisional ECM, the cell-ECM relationships through epithelial receptors, and the remodeling of the ECM by proteases (mainly matrix metalloproteinases) contribute not only to airway epithelial repair by modulating epithelial cell migration and proliferation, but also to the differentiation of repairing cells leading to the complete restoration of the wounded epithelium. A better characterization of resident stem cells and of effectors of the regeneration process is an essential prerequisite to propose new regenerative therapeutics to patients suffering from infectious/inflammatory respiratory diseases.