Precipitated sdLDL: An easy method to estimate LDL particle size
Precipitated sdLDL: An easy method to estimate LDL particle size
复制标题
DOI：
10.1002/jcla.23282
复制
发表时间：
2020-03-21
影响因子：
2.7
通讯作者：
Pinto-Sala, Xavier
中科院分区：
文献类型：
--
作者：
Fernandez-Cidon, Barbara;Candas-Estebanez, Beatriz;Pinto-Sala, Xavier
背景降低LDL-C是心血管疾病预防的主要措施，但缺血性事件的剩余风险仍然存在。目的探讨简易沉淀法分离的低密度脂蛋白胆固醇浓度（sdLDL-C）的潜在应用价值，并评价一系列临床和生化指标对sdLDL浓度的影响。使用Pearson系数（r（xy））评估它们之间的关联。结果SDLDL-C与LDL-P（r（xy）= 0.687）和LDL-Z（r（xy）= -0.603）之间存在较强的相关性，多元回归分析可解释SDLDL-C变异的56.8%（P = 8.77 ~ 10 ~ 12）。BMI、ApoB、甘油三酯、FFA和LDL-Z显示出显著贡献。其中最重要的是ApoB和LDL-Z，LDL-Z每升高1 nm，sdLDL-C降低126 nmol/L。结论sdLDL-C、LDL-Z和LDL-P之间存在明显的相关性。从大量的变量，特别是LDL-Z和apoB对sdLDL-C的影响。结果表明，LDL尺寸越小，其胆固醇浓度越高。因此，通过使用这种简单的方法测定sdLDL-C将有助于危险分层和发现心血管残余风险。
Background LDL-C lowering is the main measure in cardiovascular disease prevention but a residual risk of ischemic events still remains. Alterations of lipoproteins, specially, increase in small dense LDL (sdLDL) particles are related to this risk.Objective To investigate the potential use of sdLDL cholesterol concentration (sdLDL-C) isolated by an easy precipitation method and to assess the impact of a set of clinical and biochemical variables determined by NMR on sdLDL concentration.Methods sdLDL-C and NMR lipid profile were performed in 85 men samples. Association among them was evaluated using Pearson coefficients (r(xy)). A multivariate regression was performed to identify the influence of NMR variables on sdLDL-C.Results A strong association between sdLDL-C and LDLLDL-P (r(xy) = 0.687) and with LDL-Z (r(xy) = -0.603) was found. The multivariate regression explained a 56.8% in sdLDL-C variation (P = 8.77.10-12). BMI, ApoB, triglycerides, FFA, and LDL-Z showed a significant contribution. The most important ones were ApoB and LDL-Z; a 1nm increase (LDL-Z) leads to decrease 126 nmol/L in sdLDL-C.Conclusion The association between sdLDL-C, LDL-Z, and LDL-P is clear. From a large number of variables, especially LDL-Z and apoB influence on sdLDL-C. Results show that the smaller the LDL size, the higher their cholesterol concentration. Therefore, sdLDL-C determination by using this easy method would be useful to risk stratification and to uncover cardiovascular residual risk.