A new therapy for refractory partial epilepsy: Current shunt
A new therapy for refractory partial epilepsy: Current shunt
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难治性部分性癫痫的新疗法：电流分流
DOI：
10.1016/j.mehy.2013.07.046
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发表时间：
2013-11-01
影响因子：
4.7
通讯作者：
Kang, Xixiong
中科院分区：
文献类型：
--
作者：
Zhang, Limin;Liang, Shuli;Kang, Xixiong
尽管有最佳的治疗方法，但仍有大量癫痫患者患有难治性癫痫；因此，这些病人需要新的治疗方法。局灶性发作活动通常始于固定和局部区域，随后扩散到邻近区域或更远的区域。在癫痫发作初期，癫痫性放电会在发作病灶产生较高的电压，随后该放电向其他电压较低的区域扩散。然而，是否可以通过电流分流控制癫痫发作，使用导电微电极在大脑外的癫痫发作灶中以相对高的电压进行癫痫放电，目前尚不清楚。目前的癫痫治疗方法，包括药物、切除手术和神经调节，重点是抑制异常过度或同步的神经元活动来控制癫痫发作；因此，这些疗法的基本机制是“抑制”。相反，我们提出了一种“传导”机制，即使用传导电极的电流分流来控制癫痫发作。据我们所知，这种治疗策略以前没有报道过，我们建议这种方法可能是未来治疗难治性部分性癫痫的另一种选择。(C) 2013 Elsevier Ltd.版权所有。
A large number of epileptic patients suffer from refractory epilepsy, despite optimal treatment; thus these patients require new therapeutic approaches. Focal seizure activity is typically initiated in a fixed and localized region, which subsequently spreads to neighboring regions or more distant areas. At the initial onset of a seizure, the epileptic discharge will generate a relatively high voltage in seizure focus, and the discharge subsequently spreads to other relatively low-voltage regions. However, it is unknown whether seizure can be controlled through current shunt using a conduction microelectrode to conduct the epileptic discharge with a relatively high voltage in the seizure focus outside the brain. The current therapies for epilepsy, including drugs, resective surgery and neuromodulation, focus on inhibiting abnormal excessive or synchronous neuronal activity to control seizures; thus, the basic mechanism underlying these therapies is "inhibition". In contrast, we proposed a "conduction" mechanism, whereby a current shunt with conduction electrode is used to control seizures. To our knowledge, this therapeutic strategy has not been previously reported, and we propose that this approach might be an alternative choice for the treatment of refractory partial epilepsy in the future. (C) 2013 Elsevier Ltd. All rights reserved.