[Histopathological comparison of prostatic adenocarcinoma in Japan and the United States].
[Histopathological comparison of prostatic adenocarcinoma in Japan and the United States].
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日本与美国前列腺腺癌的组织病理学比较
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
F. Mostofi
中科院分区：
文献类型：
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作者：
M. Harada;R. Nemoto;K. Uchida;H. Akaza;K. Koiso;F. Mostofi
本文对日本和美国前列腺癌的临床病理进行了比较，并对1037例和987例前列腺癌进行了回顾性分析。所有病例均由同一病理学家(M.H.)进行组织学评估。根据日本前列腺癌总则(JGRPC)的组织分化程度、WHO分类的核分级和Gleason分级系统的应用，在事先不知道临床信息的情况下。两组患者的年龄分布略有不同。然而，这一差异似乎并不重要，因为两组患者的诊断日期存在差异。即使考虑到登记的时间差，来自日本的病例也更多地患有D期疾病。JGRPC组织学分型在所有病例中的观察到的分化发生率无显著差异，但在两组相同分期的病例中，两组之间的发生率有统计学意义。来自美国的病例更多地落在高分化腺癌上，而中分化腺癌在日本的发生率更高，即使在确诊为晚期的病例中也是如此。在日本，观察到的核级别3的发生率也更高。Gleason小学和中学五年级和9-10分在日本病例中出现的频率更高。
Histopathological comparison of clinical prostatic adenocarcinoma between Japan and the United States (US) has been made with retrospective analyses on 1,037 and 987 cases, respectively. All cases were histologically evaluated by the same pathologist (M.H.) without previous knowledge of clinical information according to application of the Japanese General Rules for Prostatic Cancer (JGRPC) based on the predominant degree of histological differentiation, the nuclear grading by WHO classification and the Gleason grading systems. The age distribution of the patients was slightly different among both groups. However, this difference appeared not to be essential, because there existed difference of the date on diagnosis between two groups. Even though considering this time difference on registration, much more cases from Japan had stage D disease. The observed incidence of the histological differentiation classified by JGRPC among over-all cases did not show significant difference, however, the incidence among the cases with same stage between two groups differed with some statistical significance. Much more cases from the US fell in well differentiated adenocarcinoma and frequency of moderately differentiated adenocarcinoma was higher in the Japanese even in the cases diagnosed at advanced stages. The observed incidence of nuclear grade 3 was also higher in the Japanese. Gleason primary and secondary grade 5 and score 9-10 appeared more frequently in the cases from Japan.(ABSTRACT TRUNCATED AT 250 WORDS)