Diastereoselective synthesis of functionalized tetrahydro-gamma-carbolines via a [3+3] cycloaddition of 2,2 '-diester aziridines with beta-(indol-2-yl)-alpha,beta-unsaturated ketones
Diastereoselective synthesis of functionalized tetrahydro-gamma-carbolines via a [3+3] cycloaddition of 2,2 '-diester aziridines with beta-(indol-2-yl)-alpha,beta-unsaturated ketones
复制标题
DOI：
10.1016/j.cclet.2019.09.002
复制
发表时间：
2020
影响因子：
9.1
通讯作者：
Deng Weiping
中科院分区：
文献类型：
--
作者：
Zou Xuejie;Liu Yangzi;Shang Shaojing;Yang Wulin;Deng Weiping
研究了Sc(OTf)3催化的2,2 ' -二酯叠氮醚与β-（吲哚-2-基）-α，β-不饱和酮的[3 + 3]环加成反应，得到了单非对映异构体的多取代四氢-γ-羰基。
A Sc(OTf)3-catalyzed [3 + 3] cycloaddition of 2,2′-diester aziridines withβ-(indol-2-yl)-α,β-unsaturated ketones was developed, affording polysubstituted tetrahydro-γ-carbolines in single diastereoisomers in good to excellent yields.