Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
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DOI：
10.1016/j.cmet.2005.09.009
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发表时间：
2005-11-01
期刊：
影响因子：
29
通讯作者：
Okamura, H
中科院分区：
文献类型：
--
作者：
Ishida, A;Mutoh, T;Okamura, H
光是昼夜节律的强大同步器，并且已知明亮的光疗法可以改善昼夜节律睡眠障碍的代谢和激素状态，尽管其机制知之甚少。在本研究中，我们发现，光诱导基因表达的肾上腺通过视交叉上核（SCN）的交感神经系统。此外，这种基因表达伴随着血浆和脑皮质酮水平的激增，而不伴随下丘脑-腺垂体轴的激活。SCN损伤后的废除，以及光诱导的肾上腺基因表达和皮质酮释放的昼夜差异，清楚地表明这种现象与生物钟密切相关。皮质类固醇反应的大小与光强度呈剂量依赖性相关。光诱导的糖皮质激素的时钟依赖性分泌调节细胞代谢以适应新的光照环境。
Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to improve metabolic and hormonal status of circadian rhythm sleep disorders, although its mechanism is poorly understood. In the present study, we revealed that light induces gene expression in the adrenal gland via the suprachiasmatic nucleus (SCN)-sympathetic nervous system. Moreover, this gene expression accompanies the surge of plasma and brain corticosterone levels without accompanying activation of the hypothalamo-adenohypophysial axis. The abolishment after SCN lesioning, and the daynight difference of light-induced adrenal gene expression and corticosterone release, clearly indicate that this phenomenon is closely linked to the circadian clock. The magnitude of corticostereone response is dose dependently correlated with the light intensity. The light-induced clock-dependent secretion of glucocorticoids adjusts cellular metabolisms to the new light-on environment.