SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens
SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens
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DOI：
10.1002/jmv.25936
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发表时间：
2020-04-30
影响因子：
12.7
通讯作者：
Gao, Zhiliang
中科院分区：
文献类型：
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作者：
Peng, Liang;Liu, Jing;Gao, Zhiliang
目的 本研究的目的是检测确诊 SARS-CoV-2 感染患者的尿液和血液标本以及肛门和口咽拭子中的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 核糖核酸 (RNA)，并将阳性结果与临床结果相关联。 方法 本研究纳入确诊 SARS-CoV-2 感染的患者。记录患者的人口统计和临床数据。使用实时定量聚合酶链反应检测尿液和血液标本以及肛门和口咽拭子中的 SARS-CoV-2 RNA。该研究注册号为（No. NCT04279782，2020 年 2 月 19 日）。结果 SARS-CoV-2 RNA 存在于所有四种样本类型中，但并非所有样本类型同时呈阳性。病毒RNA的存在不一定能预测临床症状，例如，尿液中病毒RNA的存在不一定能预测尿路症状。 结论 SARS-CoV-2可以感染多个系统，包括尿路。测试不同的样本类型可能有助于监测疾病的变化和进展以及建立预后。
Purpose The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings.Methods Patients with confirmed SARS-CoV-2 infections were included in this study. Patients' demographic and clinical data were recorded. Quantitative real-time polymerase chain reaction was used to detect SARS-CoV-2 RNA in urine and blood specimens, and anal and oropharyngeal swabs. The study is registered at (No. NCT04279782, 19 February, 2020).Results SARS-CoV-2 RNA was present in all four specimen types, though not all specimen types were positive simultaneously. The presence of viral RNA was not necessarily predictive of clinical symptoms, for example, the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms.Conclusions SARS-CoV-2 can infect multiple systems, including the urinary tract. Testing different specimen types may be useful for monitoring disease changes and progression, and for establishing a prognosis.