Exercise Intolerance In Heart Failure With Preserved Ejection Fraction.
Exercise Intolerance In Heart Failure With Preserved Ejection Fraction.
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DOI：
10.14797/mdcj-12-2-105
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发表时间：
2016-04-01
影响因子：
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通讯作者：
Hamilton, Dale J
中科院分区：
文献类型：
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作者：
Gupte, Anisha A;Hamilton, Dale J
超过50%的美国心力衰竭患者的射血分数（HFpEF）正常。运动不耐受是HFpEF的一个标志，但其病理生理机制尚不清楚。不同的病因和不完整的机制的理解，导致无效的管理策略，以改善HFpEF的结果。在射血分数降低的心力衰竭（HFrEF）治疗中有益的传统疗法，特别是神经激素阻滞，在治疗HFpEF中无效。在这篇综述中，我们讨论了HFpEF的潜在机制，并提出了支持运动作为综合管理的一个组成部分的理由。
More than 50% of Americans with heart failure have preserved ejection fraction (HFpEF). Exercise intolerance is a hallmark of HFpEF, but the pathophysiology is not well understood. Diverse etiologies and incomplete mechanistic understanding have resulted in ineffective management strategies to improve the outcomes of HFpEF. Traditional therapies that have been beneficial in the treatment of heart failure with reduced ejection fraction (HFrEF), neurohormonal blockade in particular, have not been effective in treating HFpEF. In this review, we address underlying mechanisms of HFpEF and present the rationale supporting exercise as a component of comprehensive management.