Finding the missing links among metabolites, microbes, and the host.
Finding the missing links among metabolites, microbes, and the host.
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DOI：
10.1016/j.immuni.2014.05.015
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发表时间：
2014-06-19
期刊：
影响因子：
32.4
通讯作者：
Knight R
中科院分区：
文献类型：
--
作者：
Dorrestein PC;Mazmanian SK;Knight R
人类微生物组和代谢组出人意料的多样性远远超过了人类基因组的复杂性。虽然我们现在了解了一些种群中的微生物分类和遗传谱系，但我们才刚刚开始组装计算和实验工具，以更详细地了解代谢组。然而，即使在目前有限的知识状态下，微生物和代谢物之间、微生物和免疫功能之间以及代谢物和免疫功能之间的个体联系正在建立中。在这里，我们提供了我们对这些联系的看法。我们还概述了一个系统的研究计划，它可以将这些单独的联系转化为一个更广泛的网络，使我们能够了解这些组件是如何相互作用的。这一计划将使我们能够利用微生物组、新陈代谢组和宿主免疫系统之间的联系来维持健康，或许还可以帮助我们了解如何逆转导致一系列免疫和其他疾病的过程。
The unexpected diversity of the human microbiome and metabolome far exceeds the complexity of the human genome. Although we now understand microbial taxonomic and genetic repertoires in some populations, we are just beginning to assemble the computational and experimental tools to understand the metabolome in comparable detail. However, even with the limited current state of knowledge, individual connections between microbes and metabolites, between microbes and immune function, and between metabolites and immune function are being established. Here we provide our perspective on these connections. We also outline a systematic research program that could turn these individual links into a broader network that allows us to understand how these components interact. This program will allow us to exploit connections among the microbiome, metabolome, and host immune system to maintain health, and perhaps help us understand how to reverse the processes that lead to a wide range of immune and other diseases.