Heart rate turbulence analysis in female patients with fibromyalgia
Heart rate turbulence analysis in female patients with fibromyalgia
复制标题
女性纤维肌痛患者心率波动分析
作者：
H. Dursun;E. Onrat;Emine Ercan;U. S. Demirdal;A. Avşar;U. Dundar;O. Solak;H. Toktaş
目的：纤维肌痛的特点是弥漫性肌肉骨骼疼痛和不适。有几份报告关于纤维肌痛患者的自主神经系统功能障碍。心率震荡被表示为心室相性窦性心律失常，并被认为反映了心脏自主活动。心率震荡已被证明是各种心脏异常中心源性猝死的独立且有力的预测因素。本研究的目的是确定与健康对照组相比，女性纤维肌痛患者的心率震荡是否发生了变化。方法：纳入37例纤维肌痛女性患者（平均年龄，40 ± 11岁）和35例年龄和性别匹配的健康女性对照受试者（平均年龄，42 ± 9岁）。收集所有受试者的24小时动态心电图记录，并自动计算湍流起始和湍流斜率值。结果：两组患者的基线临床特征相似。患者和对照受试者之间的湍流起始和湍流斜率测量值无显著差异（湍流起始：− 1.648 ± 1.568% vs. − 1.582 ± 1.436%，p <0.853;湍流斜率：12.933 ± 5.693 ms/RR vs. 13.639 ± 2.505 ms/RR，p <0.508）。 尽管体重指数与湍流斜率呈负相关（r =-0.258，p = 0.046），但体重指数与湍流起始之间无显著相关性（r = 0.228，p = 0.054）。 结论：据我们所知，这是第一项评估纤维肌痛患者心率震荡的研究。女性纤维肌痛患者反映心脏自主活动的心率震荡参数似乎没有改变。
OBJECTIVE: Fibromyalgia is characterized by diffuse musculoskeletal pain and discomfort. There are several reports regarding autonomic nervous system dysfunction in patients with fibromyalgia. Heart rate turbulence is expressed as ventriculophasic sinus arrhythmia and has been considered to reflect cardiac autonomic activity. Heart rate turbulence has been shown to be an independent and powerful predictor of sudden cardiac death in various cardiac abnormalities. The aim of this study is to determine whether heart rate turbulence is changed in female patients with fibromyalgia compared with healthy controls. METHODS: Thirty-seven female patients (mean age, 40±11 years) with fibromyalgia, and 35 age- and sex-matched healthy female control subjects (mean age, 42±9 years) were included. Twenty-four hours of ambulatory electrocardiography recordings were collected for all subjects, and turbulence onset and turbulence slope values were automatically calculated. RESULTS: The baseline clinical characteristics of the two groups were similar. There were no significant differences in turbulence onset and turbulence slope measures between patients and control subjects (turbulence onset: −1.648±1.568% vs. −1.582±1.436%, p ϝ 0.853; turbulence slope: 12.933±5.693 ms/RR vs. 13.639±2.505 ms/RR, p ϝ 0.508). Although body mass index was negatively correlated with turbulence slope (r ϝ −0.258, p ϝ 0.046), no significant correlation was found between body mass index and turbulence onset (r ϝ 0.228, p ϝ 0.054). CONCLUSION: To the best of our knowledge, this is the first study to evaluate heart rate turbulence in patients with fibromyalgia. It appears that heart rate turbulence parameters reflecting cardiac autonomic activity are not changed in female patients with fibromyalgia.