Comparison between Patients Hospitalized with Influenza and COVID-19 at a Tertiary Care Center.
Comparison between Patients Hospitalized with Influenza and COVID-19 at a Tertiary Care Center.
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在三级护理中心因流感和COVID-19住院的患者之间的比较。
DOI：
10.1007/s11606-021-06647-2
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发表时间：
2021-06
影响因子：
5.7
通讯作者：
Grossestreuer AV
中科院分区：
文献类型：
--
作者：
Donnino MW;Moskowitz A;Thompson GS;Heydrick SJ;Pawar RD;Berg KM;Mehta S;Patel PV;Grossestreuer AV
广泛的报道表明，2019冠状病毒病（COVID-19）和流感的特征和病程不同，但缺乏对其临床表现的详细比较。2020年3月1日至4月30日，2019冠状病毒病确诊病例的住院率、临床指标和临床结局，与2014年9月1日开始的前五个流感季节（每个季节8个月）的确诊流感病例进行了比较。马萨诸塞州波士顿市的大型三级护理教学医院确诊的COVID-19和流感住院患者患者人口统计数据和病史、死亡率、机械通气的发生率和持续时间、血管加压剂支持和肾脏替代治疗的发生率以及住院和重症监护入院。数据来自1052名流感患者和582名COVID-19患者的医疗记录。平均每8个月的流感季节有210人因流感入院，而2个月内有582人因COVID-19入院。每周需要机械通气的COVID-19患者中位数为17例（IQR：4，34），而每周需要机械通气的流感患者中位数为1例（IQR：0，2）（p=0.001）。COVID-19患者需要机械通气的可能性明显更高（31%比8%），死亡率也明显更高（20%比3%;所有患者p<0.001）。与机械通气的流感患者相比，相对更多的COVID-19患者缺乏既存疾病（25% vs 4%，p<0.001）。继发于病毒的肺炎/ARDS是COVID-19患者机械通气的主要原因（94%），而不是流感（56%）。这是一项单中心研究，可能会限制推广。在同一家医院，COVID-19导致比流感更高的每周住院率、更高的发病率和更高的死亡率。在线版本包含补充材料，可通过10.1007/s11606-021-06647-2获得。
Widespread reports suggest the characteristics and disease course of coronavirus disease 2019 (COVID-19) and influenza differ, yet detailed comparisons of their clinical manifestations are lacking. Comparison of the epidemiology and clinical characteristics of COVID-19 patients during the pandemic with those of influenza patients in previous influenza seasons at the same hospital Admission rates, clinical measurements, and clinical outcomes from confirmed COVID-19 cases between March 1 and April 30, 2020, were compared with those from confirmed influenza cases in the previous five influenza seasons (8 months each) beginning September 1, 2014. Large tertiary care teaching hospital in Boston, MA Laboratory-confirmed COVID-19 and influenza inpatients Patient demographics and medical history, mortality, incidence and duration of mechanical ventilation, incidences of vasopressor support and renal replacement therapy, and hospital and intensive care admissions. Data was abstracted from medical records of 1052 influenza patients and 582 COVID-19 patients. An average of 210 hospital admissions for influenza occurred per 8-month season compared to 582 COVID-19 admissions over 2 months. The median weekly number of COVID-19 patients requiring mechanical ventilation was 17 (IQR: 4, 34) compared to a weekly median of 1 (IQR: 0, 2) influenza patient (p=0.001). COVID-19 patients were significantly more likely to require mechanical ventilation (31% vs 8%) and had significantly higher mortality (20% vs. 3%; p<0.001 for all). Relatively more COVID-19 patients on mechanical ventilation lacked pre-existing conditions compared with mechanically ventilated influenza patients (25% vs 4%, p<0.001). Pneumonia/ARDS secondary to the virus was the predominant cause of mechanical ventilation in COVID-19 patients (94%) as opposed to influenza (56%). This is a single-center study which could limit generalization. COVID-19 resulted in more weekly hospitalizations, higher morbidity, and higher mortality than influenza at the same hospital. The online version contains supplementary material available at 10.1007/s11606-021-06647-2.
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DOI：
10.1001/jama.2020.6775
发表时间：
2020-01-01
期刊：
JAMA, Journal of the American Medical Association
影响因子：
--
作者：
Richardson, Safiya;Hirsch, Jamie S.;,
通讯作者：
,
影响因子：
3.7
作者：
Puig-Barbera, Joan;Natividad-Sancho, Angels;Burtseva, Elena
通讯作者：
Burtseva, Elena
影响因子：
19
作者：
Tolksdorf, Kristin;Buda, Silke;Haas, Walter
通讯作者：
Haas, Walter
影响因子：
56.3
作者：
Kunisaki, Ken M.;Janoff, Edward N.
通讯作者：
Janoff, Edward N.
影响因子：
5.8
作者：
Kim, Youn-Jung;Lee, Eu Sun;Lee, Yoon-Seon
通讯作者：
Lee, Yoon-Seon