NEGATIVE BEHAVIOR DURING MARITAL CONFLICT IS ASSOCIATED WITH IMMUNOLOGICAL DOWN-REGULATION
NEGATIVE BEHAVIOR DURING MARITAL CONFLICT IS ASSOCIATED WITH IMMUNOLOGICAL DOWN-REGULATION
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DOI：
10.1097/00006842-199309000-00001
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发表时间：
1993-09-01
影响因子：
3.3
通讯作者：
GLASER, R
中科院分区：
文献类型：
--
作者：
KIECOLTGLASER, JK;MALARKEY, WB;GLASER, R
尽管发病率和死亡率的增加确实与社会孤立和不太令人满意的人际关系有关，但人们对潜在的生物心理社会机制知之甚少。我们评估了 90 对新婚夫妇的问题解决行为和免疫功能变化，这些新婚夫妇被送往医院研究室 24 小时。在 30 分钟的婚姻问题讨论中表现出更多消极或敌对行为的受试者在 24 小时内的四项功能性免疫测定（自然杀伤细胞裂解、对两种有丝分裂原的胚细胞反应以及对 T3 受体单克隆抗体的增殖反应）中表现出与低阴性受试者相比更大的下降，以及总 T 淋巴细胞和辅助 T 淋巴细胞数量的更大增加。高阴性受试者比低阴性受试者具有更高的潜伏 Epstein-Barr 病毒抗体滴度，这与免疫功能下调一致。女性比男性更有可能表现出负面的免疫学变化。对婚姻问题的讨论也导致血压升高幅度更大，高阴性受试者比低阴性受试者血压升高的时间更长。积极或支持性的解决问题的行为与免疫或血压变化无关。这些生理差异特别值得注意，因为两组的婚姻满意度都很高，而且夫妻是根据严格的心理和身体健康标准选择的。这些数据为人际关系和免疫功能之间的联系提供了额外的支持。
Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem-solving behaviors and changes in immune function in 90 newlywed couples who were admitted to a hospital research unit for 24 hours. Subjects who exhibited more negative or hostile behaviors during a 30-minute discussion of marital problems showed greater decrements over 24 hours relative to low negative subjects on four functional immunological assays (natural killer cell lysis, blastogenic response to two mitogens, and the proliferative response to a monoclonal antibody to the T3 receptor), as well as larger increases in the numbers of total T lymphocytes and helper T lymphocytes. High negative subjects had higher antibody titers to latent Epstein-Barr virus than low negative subjects, consistent with down-regulated immune function. Women were more likely to show negative immunological changes than men.The discussion of marital problems also led to larger increases in blood pressure that remained elevated longer in high negative subjects than low negative subjects. Positive or supportive problem-solving behaviors were not related to either immunological or blood pressure changes.These physiological differences were particularly noteworthy because marital satisfaction was high in both groups, and couples had been selected on the basis of stringent mental and physical health criteria. These data provide additional support for the link between personal relationships and immune function.