Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study.
Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study.
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DOI：
10.1038/srep19320
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发表时间：
2016-01-13
影响因子：
4.6
通讯作者：
Cheng CY
中科院分区：
文献类型：
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作者：
Tham YC;Aung T;Fan Q;Saw SM;Siantar RG;Wong TY;Cheng CY
我们在一个多种族的亚洲人群中研究了眼内压（IOP）和近视对原发性开角型青光眼（POAG）风险的联合作用。共纳入新加坡眼病流行病学研究的9,422名参与者（18,469只眼）。其中213例（273眼）为POAG。所有参与者都接受了标准化检查。用Logistic回归模型分析眼压和近视对POAG的独立和联合作用。广义估计方程模型用于解释眼睛之间的相关性。在调整相关协变量后，更高的IOP、更长的眼轴长度和更负的等效球镜与POAG独立相关（所有P ≤ 0.005）。观察到眼压和近视对POAG的显著交互作用（P交互作用= 0.025）。与无近视眼（>-0.5屈光度）且IOP <20 mmHg的眼睛相比，中高度近视眼（<-3.0屈光度）伴高IOP（≥20 mmHg）的眼睛患POAG的可能性为4.27倍（95% CI，2.10-8.69）。AL ≥25.5 mm和高眼压（≥20 mmHg）的患眼发生POAG的可能性是AL <23.5 mm和低眼压（<20 mmHg）的16.22倍（95%CI，7.73 ~ 34.03）。这些发现可能为POAG的病理生理学提供更多的见解，尤其与亚洲人群相关。
We examined the joint effects of intraocular pressure (IOP) and myopia on the risk of primary open angle glaucoma (POAG) in a multi-ethnic Asian population. A total of 9,422 participants (18,469 eyes) in the Singapore Epidemiology of Eye Diseases Study were included. Of them, 213 subjects (273 eyes) had POAG. All participants underwent standardised examinations. The independent and joint effects of IOP and myopia on POAG were examined using logistic regression models. Generalised estimating equation models were used to account for correlation between eyes. Higher IOP, longer axial length, and more negative spherical equivalent were independently associated with POAG, after adjusting for relevant covariates (all P ≤ 0.005). Significant interaction between IOP and myopia on POAG was observed (P interaction = 0.025). Eyes with moderate-to-high myopia (<−3.0 dioptres) with high IOP (≥20 mmHg) were 4.27 times (95% CI, 2.10–8.69) likely to have POAG, compared to eyes without myopia (>−0.5 dioptres) and with IOP <20 mmHg. Eyes with AL of ≥25.5 mm and high IOP (≥20 mmHg) were 16.22 times (95% CI, 7.73 to 34.03) likely to have POAG, compared to eyes with shorter AL (<23.5 mm) and lower IOP (<20 mmHg). These findings may provide additional insights into the pathophysiology of POAG and are particularly relevant for Asian populations.