Biomechanical properties of in vivo human skin from dynamic optical coherence elastography.
Biomechanical properties of in vivo human skin from dynamic optical coherence elastography.
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DOI：
10.1109/tbme.2009.2033464
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Boppart SA
中科院分区：
文献类型：
--
作者：
Liang X;Boppart SA
动态光学相干弹性成像是一种基于机械表面波传播的体内皮肤生物力学特性测定方法。定量杨氏模量是在人体皮肤上从不同部位、方向和频率测量的。皮肤厚度，包括不同层的测量，也同时测量。实验结果表明，不同皮肤部位、与兰格线平行和正交方向、不同皮肤水合状态下的测量值存在显著差异。结果还表明，不同驱动频率的表面波代表了不同层次深度的皮肤生物力学特性。该光学测量技术具有微米级分辨率、无创成像和光学相干断层扫描技术的实时处理等特点，在皮肤医学中具有测量皮肤生物力学特性的巨大潜力。
Dynamic optical coherence elastography is used to determine in vivo skin biomechanical properties based on mechanical surface wave propagation. Quantitative Young’s moduli are measured on human skin from different sites, orientations, and frequencies. Skin thicknesses, including measurements from different layers, are also measured simultaneously. Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langer’s lines, and under different skin hydration states. Results also suggest surface waves with different driving frequencies represent skin biomechanical properties from different layers in depth. With features such as micrometer-scale resolution, noninvasive imaging, and real-time processing from the optical coherence tomography technology, this optical measurement technique has great potential for measuring skin biomechanical properties in dermatology.