Natural cellular inhibitors of caspases
Natural cellular inhibitors of caspases
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DOI：
10.1016/s0278-5846(03)00017-4
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发表时间：
2003-04
影响因子：
5.6
通讯作者：
A. LeBlanc
中科院分区：
文献类型：
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作者：
A. LeBlanc
细胞死亡在许多疾病中的关键作用是显而易见的，并刺激了深入的研究，以了解凋亡途径的调节。Caspase活化是许多凋亡途径的核心。近年来，对多种细胞系和疾病中caspase活化和活性调控的研究揭示了调节细胞存活或死亡的高度复杂的机制。在这篇综述中，主要的天然细胞抗半胱天冬酶因子被描述，特别关注的抑制剂，防止活性半胱天冬酶使细胞不可逆的破坏。目前已知的caspase抑制剂主要是凋亡蛋白抑制剂（IAP），本文综述了IAP的特点、表达调控以及IAP的作用机制。然而，其他蛋白质包括Bcl-2家族成员、热休克蛋白、caspase样诱饵、钙蛋白酶和蛋白酶，以及磷酸肌苷形式的脂质部分也可以作为caspase抑制剂。本文描述了目前对这些非iap因子抑制的了解。
The crucial role of cell death in many diseases is obvious and has spurred intense research to understand the regulation of apoptotic pathways. Caspase activation is central to many of the apoptotic pathways. In recent years, the study of the regulation of caspase activation and activity in various cell lines and in diseases has revealed highly complex mechanisms regulating cell survival or cell death. In this review, the major natural cellular anticaspase factors are described with particular attention to the inhibitors that prevent active caspases from committing the cell to irreversible destruction. The major group of caspase inhibitors known is the inhibitor of apoptosis proteins (IAP) and this review describes the characteristics of IAP, regulation of IAP expression, and mechanisms of action of IAP. However, other proteins including Bcl-2 family members, heat shock proteins, caspase-like decoy, calpains and proteases, and lipid moieties in the form of phosphoinositides also can function as caspase inhibitors. The current knowledge of the inhibition of these non-IAP factors is described herein.