Sasa quelpaertensis Nakai extract suppresses porcine reproductive and respiratory syndrome virus replication and modulates virus-induced cytokine production.
Sasa quelpaertensis Nakai extract suppresses porcine reproductive and respiratory syndrome virus replication and modulates virus-induced cytokine production.
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DOI：
10.1007/s00705-015-2469-0
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发表时间：
2015-08
影响因子：
2.7
通讯作者：
Lee C
中科院分区：
文献类型：
--
作者：
Kang H;Lee C
尽管 Sasa quelpaertensis Nakai（一种矮竹）对健康具有多种有益作用，但其抗病毒作用仍有待阐明。猪繁殖与呼吸综合征病毒（PRRSV）是猪最具破坏性的病毒病原体之一，对全球猪肉业产生重大经济影响。因此，本研究旨在确定 Sasa quelpaertensis Nakai 提取物 (SQE) 是否能抑制培养的猪肺泡巨噬细胞 (PAM) 中的 PRRSV 感染。我们的结果表明，SQE 治疗以剂量依赖性方式抑制 PRRSV 的复制。发现 SQE 对 PRRSV 复制的抗病毒活性主要在感染后早期发挥作用。 SQE 治疗导致病毒基因组和亚基因组 RNA 合成、病毒蛋白表达和子代病毒产量显着减少。值得注意的是，感染 PRRSV 的 PAM 细胞中促炎细胞因子的产生在 SQE 的存在下受到调节。总而言之，我们的数据表明 SQE 有潜力作为 PRRSV 的治疗剂。本文的在线版本 (doi:10.1007/s00705-015-2469-0) 包含补充材料，可供授权用户使用。
Although Sasa quelpaertensis Nakai, a dwarf bamboo, is known to exert a variety of beneficial effects on health, its antiviral effect remains to be elucidated. Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating viral pathogens of swine and has a substantial economic impact on the global pork industry. Therefore, the present study was conducted to determine whether Sasa quelpaertensis Nakai extract (SQE) inhibits PRRSV infection in cultured porcine alveolar macrophages (PAMs). Our results demonstrated that SQE treatment suppressed the replication of PRRSV in a dose-dependent manner. The antiviral activity of SQE on PRRSV replication was found to be primarily exerted at early times postinfection. Treatment with SQE resulted in marked reduction of viral genomic and subgenomic RNA synthesis, viral protein expression, and progeny virus production. Notably, pro-inflammatory cytokine production in PAM cells infected with PRRSV was shown to be modulated in the presence of SQE. Taken together, our data indicate that SQE has potential as a therapeutic agent against PRRSV. The online version of this article (doi:10.1007/s00705-015-2469-0) contains supplementary material, which is available to authorized users.
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影响因子：
5
作者：
Fang Y;Snijder EJ
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影响因子：
2.2
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