Estimation of levels of gene flow from DNA sequence data.
Estimation of levels of gene flow from DNA sequence data.
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DOI：
10.1093/genetics/132.2.583
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发表时间：
1992-10
期刊：
影响因子：
3.3
通讯作者：
R. Hudson;M. Slatkint;W. Maddison
中科院分区：
文献类型：
--
作者：
R. Hudson;M. Slatkint;W. Maddison
我们比较了两种方法的效用估计的平均水平的基因流的DNA序列数据。一种方法是根据多态位点的频率估计FST，将每个位点视为单独的位点。另一种方法是基于计算与从其序列推断的基因树一致的迁移事件的最小数目。我们比较了这两种方法的性能，由计算机模拟程序，假设突变的无限网站模型，并假设迁移的岛屿模型所产生的数据。我们发现，在一般情况下，当没有重组，分支方法比FST表现更好，而相反的重组率类似于真核细胞核基因中发现的，虽然FST表现更好的所有重组率非常低的迁移水平（Nm = 0.1）。
We compare the utility of two methods for estimating the average levels of gene flow from DNA sequence data. One method is based on estimating FST from frequencies at polymorphic sites, treating each site as a separate locus. The other method is based on computing the minimum number of migration events consistent with the gene tree inferred from their sequences. We compared the performance of these two methods on data that were generated by a computer simulation program that assumed the infinite sites model of mutation and that assumed an island model of migration. We found that in general when there is no recombination, the cladistic method performed better than FST while the reverse was true for rates of recombination similar to those found in eukaryotic nuclear genes, although FST performed better for all recombination rates for very low levels of migration (Nm = 0.1).