Estimating the time and temperature relationship for causation of deep-partial thickness skin burns
Estimating the time and temperature relationship for causation of deep-partial thickness skin burns
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DOI：
10.1016/j.burns.2015.06.002
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发表时间：
2015-12-01
期刊：
影响因子：
2.7
通讯作者：
Diller, Kenneth R.
中科院分区：
文献类型：
--
作者：
Abraham, John P.;Plourde, Brian;Diller, Kenneth R.
本研究的目的是开发并提出一种简单的程序，用于评估导致深度局部厚度烧伤的温度和暴露时间条件以及烧伤后热环境对过程的影响。设计并应用了一个计算模型来预测皮肤烧伤达到深部损伤水平所需的时间。该模型包括多个组织层，包括表皮、真皮、皮下组织和皮下组织。模拟暴露温度范围为 62.8 至 87.8 摄氏度（145-190 华氏度）。研究了两种情况。第一种也是最坏的情况是直接接触水（其特点是对流系数大），接触后衣服留在皮肤上。第二个案例是被烫伤，随后立即用冷水（20 摄氏度）清洗皮肤。对于这两种情况，均应用阿伦尼乌斯损伤模型，计算并比较不同烧伤后治疗的损伤程度和深度。此外，将损伤值与文献中的实验数据进行比较，以评估数值方法的验证。结果发现，损伤程度的临床观察结果与计算值一致。此外，冷水淹没比衣服隔热套更快地降低皮肤温度，并导致烧伤程度适度降低。 (C) 2015 Elsevier Ltd 和 ISBI。版权所有。
The objective of this study is to develop and present a simple procedure for evaluating the temperature and exposure-time conditions that lead to causation of a deep-partial thickness burn and the effect that the immediate post-burn thermal environment can have on the process. A computational model has been designed and applied to predict the time required for skin burns to reach a deep-partial thickness level of injury. The model includes multiple tissue layers including the epidermis, dermis, hypodermis, and subcutaneous tissue. Simulated exposure temperatures ranged from 62.8 to 87.8 degrees C (145-190 degrees F). Two scenarios were investigated. The first and worst case scenario was a direct exposure to water (characterized by a large convection coefficient) with the clothing left on the skin following the exposure. A second case consisted of a scald insult followed immediately by the skin being washed with cool water (20 degrees C). For both cases, an Arrhenius injury model was applied whereby the extent and depth of injury were calculated and compared for the different post-bum treatments. In addition, injury values were compared with experiment data from the literature to assess verification of the numerical methodology. It was found that the clinical observations of injury extent agreed with the calculated values. Furthermore, inundation with cool water decreased skin temperatures more quickly than the clothing insulating case and led to a modest decrease in the burn extent. (C) 2015 Elsevier Ltd and ISBI. All rights reserved.