Computatio-nal study of LDL mass transport in the artery wall
Computatio-nal study of LDL mass transport in the artery wall
复制标题
动脉壁中低密度脂蛋白质量转运的计算研究
DOI：
10.1007/s12573-011-0034-3
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发表时间：
2011
影响因子：
--
通讯作者：
Hirokazu Ozono
中科院分区：
文献类型：
--
作者：
Shigeru Tada;Hirokazu Ozono
本文提出了LDL在动脉壁上对流-扩散运输的二维（2D）数值模拟，以及壁面剪切应力梯度（WSSG）依赖的平滑肌细胞（SMCs） LDL消耗。SMCs被建模为嵌入在连续多孔介质中的固体圆柱形柱阵列，该多孔介质代表间隙性蛋白聚糖和胶原纤维基质。将动脉介质与内膜分开的内部弹性层（IEL）被建模为水和低密度脂蛋白的不可渗透屏障，除了假设在IEL上均匀分布的门静脉孔。这些预测证明了低密度脂蛋白在介质中的运输和摄取的一系列有趣的特征。对于门骨孔下方的细胞，SMCs的LDL摄取高度依赖于WSSG。此外，SMCs消耗LDL的速率也受到门骨孔直径的影响。这将有助于理解跨壁转运过程在动脉粥样硬化发生和发展中的作用。
A two-dimensional (2D) numerical simulation of convective–diffusive transport of LDL in the artery wall, coupled with the wall shear stress gradient (WSSG)-dependent LDL consumption of smooth muscle cells (SMCs) is presented. SMCs are modeled as an array of solid cylindrical pillars embedded in a continuous porous media which represents the interstitial proteoglycan and collagen fiber matrix. The internal elastic lamina (IEL), which separates the artery media from the intima, is modeled as an impermeable barrier to both water and LDL except for the fenestral pores that are assumed to be uniformly distributed over the IEL. The predictions demonstrate a range of interesting features of LDL transport and uptake in the media. For cells immediately below the fenestral pores, LDL uptake of SMCs is highly dependent on WSSG. Moreover, the rate of LDL consumption by SMCs is also affected by the diameter of the fenestral pore. This will be helpful in understanding the involvement of transmural transport processes in the initiation and development of atherosclerosis.