Role of aldosterone in the remnant kidney model in the rat
Role of aldosterone in the remnant kidney model in the rat
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DOI：
10.1172/jci118867
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发表时间：
1996-08-15
影响因子：
15.9
通讯作者：
Hostetter, TH
中科院分区：
文献类型：
--
作者：
Greene, EL;Kren, S;Hostetter, TH
肾素-血管紧张素-醛固酮系统（RAAS）参与了残肾持续性损伤。我们的研究评估了醛固酮在该模型中的重要性以及醛固酮对干扰RAAS的药物的反应。假手术大鼠、未治疗的残余大鼠（REM）、氯沙坦和依那普利治疗的REM大鼠REM AIIA组（REM AIIA + ALDO组）和REM AIIA组（REM AIIA + ALDO组）。REM大鼠肾上腺较大，血浆醛固酮升高> 10倍。与REM相比，AIIA大鼠表现出对醛固酮增多症的显著抑制以及蛋白尿、高血压和肾小球硬化的显著减弱，REM AIIA + ALDO大鼠表现出比REM AIIA大鼠更大的蛋白尿、高血压和肾小球硬化。实际上，通过4周的观察，实验疾病的所有这些特征在REM AIIA + ALDO和未治疗的REM中在程度上相似，在单独的REM大鼠中，螺内酯给药没有减少肾小球硬化，但确实短暂地减少蛋白尿，降低动脉压，减轻心脏肥大。总之，醛固酮有助于残肾模型中的高血压和肾损伤。
The renin-angiotensin-aldosterone system (RAAS) participates in the injury sustained by the remnant kidney, Our studies assessed the importance of aldosterone in that model and the response of aldosterone to drugs interfering with the RAAS, Initially, four groups of rats were studied: SHAM-operated rats, untreated remnant rats (REM), REM rats treated with losartan and enalapril (REM AIIA), and REM AIIA rats infused with exogenous aldosterone (REM AIIA + ALDO), The last group was maintained with aldosterone levels comparable to those in untreated REM rats by constant infusion of exogenous aldosterone. REM rats had larger adrenal glands and a > 10-fold elevation in plasma aldosterone compared to SHAM, REM. AIIA rats demonstrated significant suppression of the hyperaldosteronism as well as marked attenuation of proteinuria, hypertension, and glomerulosclerosis compared to REM, REM AIIA + ALDO rats manifested greater proteinuria, hypertension, and glomerulosclerosis than REM AIIA rats, Indeed, by 4 wk of observation all of these features of the experimental disease were similar in magnitude in REM AIIA + ALDO and untreated REM, In separate REM rats spironolactone administration did not reduce glomerular sclerosis but did transiently reduce proteinuria, lowered arterial pressure, and lessened cardiac hypertrophy, In summary, aldosterone contributes to hypertension and renal injury in the remnant kidney model.