MECHANISMS OF SCHISTOSOMA-MANSONI EGG EXCRETION - PARASITOLOGICAL OBSERVATIONS IN IMMUNOSUPPRESSED MICE RECONSTITUTED WITH IMMUNE SERUM
MECHANISMS OF SCHISTOSOMA-MANSONI EGG EXCRETION - PARASITOLOGICAL OBSERVATIONS IN IMMUNOSUPPRESSED MICE RECONSTITUTED WITH IMMUNE SERUM
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DOI：
10.1111/j.1365-3024.1983.tb00722.x
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发表时间：
1983-01-01
影响因子：
2.2
通讯作者：
DOENHOFF, M
中科院分区：
文献类型：
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作者：
DUNNE, DW;HASSOUNAH, O;DOENHOFF, M
通过切除成年胸腺和注射兔抗小鼠胸腺细胞血清剥夺T细胞的CBA小鼠不能分泌同样多的S。作为免疫学上完整的对照。这种寄生虫卵排泄的失败并不明显归因于产生的粪便物质量的任何显著变化，或蠕虫负荷大小的变化，或由于T细胞剥夺而导致的组织中卵的数量或分布。S.从T细胞剥夺小鼠新鲜分离的曼氏卵静脉注射到正常动物中，诱导肺肉芽肿，其与注射来自正常供体的卵诱导的肉芽肿大小相同。S.曼氏虫卵排泄不受组织中虫卵密度的影响，因为组织结合虫卵的数量与粪便中检测到的虫卵数量之间存在线性关系。用免疫抑制剂醋酸氢化可的松治疗感染的小鼠，也能显著降低虫卵排泄率。注射来自慢性感染的正常小鼠供体的血清增加了T细胞剥夺和类固醇治疗的小鼠的卵子排泄率，但通过每日血清注射获得的重建程度仅部分相对于正常的卵子排泄率。用眼镜蛇毒因子处理感染的正常或剥夺血清的小鼠，以降低血清补体[成分] C3水平，对S.曼氏卵排泄
CBA mice deprived of their T cells by a combination of adult thymectomy and injection of rabbit anti-mouse thymocyte serum failed to excrete as many S. mansoni eggs in their feces as immunologically intact controls. This failure of parasite egg excretion was not obviously attributable to any marked change in the amount of fecal matter produced, or to a change in the size of the worm burden, or to the number or distribution of eggs in the tissues as a result of T-cell deprivation. S. mansoni eggs freshly isolated from T-cell-deprived mice and injected i.v. into normal animals, induced lung granulomas which were the same size as those induced by injection of eggs from normal donors. The rate of S. mansoni egg excretion was not affected by the density of eggs in the tissues, inasmuch as there was a linear relationship between the number of tissue-bound eggs and the number of eggs detected in the feces. Treatment of infected mice with the immunosuppressant hydrocortisone acetate also induced a marked reduction in the rate of egg excretion. Injections of serum derived from chronically infected normal mouse donors increased the rate of egg excretion in both T-cell-deprived and steroid-treated mice, but the degree of reconstitution obtained by daily serum injections was only partial relative to normal egg excretion rates. Treatment of infected normal or deprived serum-treated mice with cobra venom factor to reduce serum complement [component] C3 levels had no effect on the rate of S. mansoni egg excretion.