Influence of saliva on the oral microbiota
Influence of saliva on the oral microbiota
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DOI：
10.1111/prd.12098
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发表时间：
2016-02-01
影响因子：
18.6
通讯作者：
Devine, Deirdre A.
中科院分区：
文献类型：
--
作者：
Marsh, Philip D.;Thuy Do;Devine, Deirdre A.
唾液通过多种机制在决定口腔微生物区系的组成和活性方面发挥着重要作用。分子，主要来自唾液，在口腔表面形成一层调节膜，从而为细菌附着提供受体。附着的细胞使用唾液成分，如糖蛋白，作为它们生长的主要营养来源。口腔细菌以顺序和协调的方式工作，分解这些结构复杂的分子。唾液还将生物膜中的pH缓冲到中性附近，创造了一个有利于许多口腔细菌生长的环境，这些细菌为宿主提供了重要的好处。适应性和天然宿主防御的组成部分由唾液提供，这些成分通常协同作用，并且处于亚致死浓度，因此宿主和驻留的微生物群之间形成了复杂的关系。如果唾液流动受到干扰，就会迅速发生生物失调。
Saliva plays a major role in determining the composition and activity of the oral microbiota, via a variety of mechanisms. Molecules, mainly from saliva, form a conditioning film on oral surfaces, thus providing receptors for bacterial attachment. The attached cells use saliva components, such as glycoproteins, as their main source of nutrients for growth. Oral bacteria work sequentially and in a concerted manner to catabolize these structurally complex molecules. Saliva also buffers the pH in the biofilm to around neutrality, creating an environment which is conducive to the growth of many oral bacteria that provide important benefits to the host. Components of the adaptive and innate host defences are delivered by saliva, and these often function synergistically, and at sublethal concentrations, so a complex relationship develops between the host and the resident microbiota. Dysbiosis can occur rapidly if the flow of saliva is perturbed.