High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia
High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia
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DOI：
10.1016/j.rmed.2004.03.008
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发表时间：
2004-10-01
影响因子：
4.3
通讯作者：
Kohno, S
中科院分区：
文献类型：
--
作者：
Yoshioka, S;Mukae, H;Kohno, S
据报道，趋化因子如激活调节、正常 T 细胞表达和分泌 (RANTES)、单核细胞趋化蛋白 (MCP)-1、单核细胞炎症蛋白 (MIP)-1α 在间质性肺疾病的发病机制中发挥重要作用。在特发性间质性肺炎 (IIP) 中，与普通间质性肺炎 (UIP) 相比，非特异性间质性肺炎 (NSIP) 的支气管肺泡灌洗 (BAL) 液中淋巴细胞百分比升高。这些趋化因子是 NSIP 中淋巴细胞吸引至肺部的候选介质。因此，我们测量了 15 名特发性 NSIP 患者、20 名特发性 UIP 患者、22 名结节病患者和 12 名健康志愿者的 BAL 液中 RANTES、MCP-1 和 MIP1-α 水平，以使用酶联免疫吸附测定评估这些趋化因子的贡献。 NSIP患者BAL液中RANTES水平显着高于健康志愿者（P < 0.01）、UIP和结节病患者（P < 0.05）。在MCP-1中，NSIP和UIP患者BAL液中的水平显着高于健康志愿者和结节病患者（P < 0.01）。这些结果表明，BAL 液中的 RANTES 和 MCP-1 可能在特发性 NSIP 以及其他间质性肺疾病中炎症细胞募集至肺部的过程中发挥重要作用。 (C) 2004 Elsevier Ltd. 保留所有权利。
Chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, monocyte inflammatory protein (MIP)-1alpha have been reported to play an important rote in the pathogenesis of interstitial lung diseases. Among idiopathic interstitial pneumonia (IIP), nonspecific interstitial pneumonia (NSIP) has elevated percentages of lymphocytes in bronchoalveolar lavage (BAL) fluid compared with usual interstitial pneumonia (UIP). These chemokines are candidate mediators for lymphocyte attraction to the lung in NSIP. Therefore, we measured the BAL fluid levels of RANTES, MCP-1 and MIP1-alpha in 15 patients with idiopathic NSIP, 20 with idiopathic UIP, 22 with sarcoidosis and 12 healthy volunteers to evaluate the contribution of these chemokines using enzyme-linked immunosorbent assays. The levels of RANTES in BAL fluid were significantly higher in patients with NSIP compared with healthy volunteers (P < 0.01), UIP and sarcoidosis (P < 0.05). In MCP-1, the Levels in BAL fluid of NSIP and UIP patients were significantly elevated compared with healthy volunteers and sarcoidosis patients (P < 0.01). These results suggest that RANTES and MCP-1 in BAL fluid may play an important role in inflammatory cell recruitment to the lung in idiopathic NSIP as well as other interstitial lung diseases. (C) 2004 Elsevier Ltd. All rights reserved.