Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.
Coordinated reset neuromodulation for Parkinson's disease: proof-of-concept study.
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DOI：
10.1002/mds.25923
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发表时间：
2014-11
影响因子：
8.6
通讯作者：
Tass, Peter Alexander
中科院分区：
文献类型：
--
作者：
Adamchic, Ilya;Hauptmann, Christian;Barnikol, Utako Brigit;Pawelczyk, Norbert;Popovych, Oleksandr;Barnikol, Thomas Theo;Silchenko, Alexander;Volkmann, Jens;Deuschl, Guenter;Meissner, Wassilios G.;Maarouf, Mohammad;Sturm, Volker;Freund, Hans-Joachim;Tass, Peter Alexander
帕金森病（PD）基底节神经元活动异常同步化的发现促使了新的神经调节范式的发展。协调重置神经调节旨在专门抵消过度同步，并诱导病理性突触连接和神经元同步的累积遗忘。在该前瞻性病例系列中，根据包括电生理记录和临床评估的标准化方案，在协调复位神经调节前后对6例PD患者进行了评价。在三个刺激日期间，在外部环境中对六名PD患者进行了丘脑底核（STN）的协调重置神经调节，导致β带活动显着且累积减少，这与运动功能的显着改善相关。这些结果突出了PD患者脑电活动的协调复位神经调节的潜在影响，并鼓励进一步开发这种方法作为PD患者常规高频脑深部电刺激的替代方法。© 2014作者。出版社：Wiley Periodicals，Inc.国际帕金森和运动障碍协会（International Parkinson and Movement Disorder Society）
The discovery of abnormal synchronization of neuronal activity in the basal ganglia in Parkinson's disease (PD) has prompted the development of novel neuromodulation paradigms. Coordinated reset neuromodulation intends to specifically counteract excessive synchronization and to induce cumulative unlearning of pathological synaptic connectivity and neuronal synchrony. In this prospective case series, six PD patients were evaluated before and after coordinated reset neuromodulation according to a standardized protocol that included both electrophysiological recordings and clinical assessments. Coordinated reset neuromodulation of the subthalamic nucleus (STN) applied to six PD patients in an externalized setting during three stimulation days induced a significant and cumulative reduction of beta band activity that correlated with a significant improvement of motor function. These results highlight the potential effects of coordinated reset neuromodulation of the STN in PD patients and encourage further development of this approach as an alternative to conventional high-frequency deep brain stimulation in PD. © 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
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