CHARACTERIZATION OF CONOTRUNCAL MALFORMATIONS FOLLOWING ABLATION OF CARDIAC NEURAL CREST
CHARACTERIZATION OF CONOTRUNCAL MALFORMATIONS FOLLOWING ABLATION OF CARDIAC NEURAL CREST
复制标题
DOI：
10.1002/ar.1092130112
复制
发表时间：
1985-01-01
影响因子：
--
通讯作者：
HAYS, BM
中科院分区：
文献类型：
--
作者：
KIRBY, ML;TURNAGE, KL;HAYS, BM
神经嵴细胞从颅区的神经褶皱填充流出道的发育鸡心脏。去除这一区域的前迁移神经嵴已被证明以前导致高比例的圆锥动脉干畸形。本研究的目的是更精确地确定正常圆锥干发育所需的前迁移神经嵴区域。使用显微烧灼器消融不同区域和长度的前迁移颅神经嵴。圆锥干发育中的三个缺陷与神经嵴消融显著相关。这些是高位室间隔缺损，单支流出道血管起源于右心室，单支流出道血管覆盖室间隔。
Neural crest cells from the cranial region of the neural fold populate the outflow tract of the developing chick heart. Removal of this region of premigratory neural crest has been shown previously to result in a high percentage of conotruncal malformations. The present study was undertaken to define more precisely the regions of premigratory neural crest which are needed for normal conotruncal development. Various regions and lenghts of premigratory cranial neural crest were ablated using microcautery. Three defects in conotruncal development were significantly correlated with the neural crest ablation. These were high venticular septal defect, single outflow vessel originating from the right ventricle, and single outflow vessel overriding the ventricular septum.