Sex-specific repression of dachshund is required for Drosophila sex comb development
Sex-specific repression of dachshund is required for Drosophila sex comb development
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DOI：
10.1016/j.ydbio.2013.12.017
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发表时间：
2014-02-15
影响因子：
2.7
通讯作者：
Kopp, Artyom
中科院分区：
文献类型：
--
作者：
Atallah, Joel;Vurens, Gerard;Kopp, Artyom
新形态结构的起源需要。建立新的遗传调控回路，以控制它们的发育，从最初的特化到终末分化。上游调控基因通常是最先被发现的，而将新的调控信息转化为表型多样性的机制往往仍然不清楚。特别是，在许多动物谱系中进化出的复杂的性别特异性结构不可避免地受到性别决定基因的控制，但性二型细胞分化的遗传基础很少被理解。在这份报告中，我们研究的作用腊肠犬（dachshund），在感觉器官和附属物的发展，在性梳，最近在一些果蝇物种中发现的男性特有的结构具有高度保守的功能的基因。我们发现，在变态过程中，限制性梳发展到适当的腿区域的行为。性别决定途径的局部抑制是必要的男性特定的性梳刚毛的形态发生。dac的这种蛹功能与其早期在腿部模式中的作用是分开的，并且该阶段的Dac不依赖于幼虫期dac的主要调节因子Distalless（Dll）的蛹表达。在蛹发育过程中，Dll作用于性梳周围的上皮细胞，以促进性梳旋转，这是一个由协调细胞重排驱动的复杂细胞过程。我们的研究结果表明，具有良好保守的发育功能的基因可以在发育的后期重新使用，以调节最近进化的性状。这种基因协同选择的模式可能是进化创新的重要驱动力。(C)2013 Elsevier Inc. All rights reserved.
The origin of new morphological structures requires. the establishment of new genetic regulatory circuits to control their development, from initial specification to terminal differentiation. The upstream regulatory genes are usually the first to be identified, while the mechanisms that translate novel regulatory information into phenotypic diversity often remain obscure. In particular, elaborate sex-specific structures that have evolved in many animal lineages are inevitably controlled by sex-determining genes, but the genetic basis of sexually dimorphic cell differentiation is rarely understood. In this report, we examine the role of dachshund (dac), a gene with a deeply conserved function in sensory organ and appendage development, in the sex comb, a recently evolved male-specific structure found in some Drosophila species. We show that dac acts during metamorphosis to restrict sex comb development to the appropriate leg region. Localized repression of dac by the sex determination pathway is necessary for male-specific morphogenesis of sex comb bristles. This pupal function of dac is separate from its earlier role in leg patterning, and Dac at this stage is not dependent on the pupal expression of Distalless (Dll), the main regulator of dac during the larval period. Dll acts in the epithelial cells surrounding the sex comb during pupal development to promote sex comb rotation, a complex cellular process driven by coordinated cell rearrangement. Our results show that genes with well-conserved developmental functions can be re-used at later stages in development to regulate more recently evolved traits. This mode of gene co-option may be an important driver of evolutionary innovations. (C) 2013 Elsevier Inc. All rights reserved.