Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
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DOI：
10.1126/science.277.5332.1659
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发表时间：
1997-09-12
期刊：
影响因子：
56.9
通讯作者：
Meaney, MJ
中科院分区：
文献类型：
--
作者：
Liu, D;Diorio, J;Meaney, MJ
母体护理的差异影响大鼠神经内分泌反应的个体差异的发展。成年后，在幼崽出生后的前10天，幼崽表现出更多的舔和梳理，其后代对急性应激的血浆促肾上腺皮质激素和皮质酮反应减少，海马糖皮质激素受体信使RNA表达增加，糖皮质激素反馈敏感性增强，下丘脑促肾上腺皮质激素释放激素信使RNA水平降低。每一项指标都与母亲舔脸和梳妆的频率显著相关(所有r>；-0.6)。这些发现表明，母亲的行为对子代的下丘脑-垂体-肾上腺的压力反应起到了“编程”作用。
Variations in maternal care affect the development of individual differences in neuroen-docrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r's > -0.6). These findings suggest that maternal behavior serves to ''program'' hypothalamic-pituitary-adrenal responses to stress in the offspring.