Palladium-Catalyzed Three-Component Coupling of 1,1-Dibromoalkenes, Vinylzinc Chloride, and Soft Nucleophiles: One-Pot Synthesis of 1,3-Disubstituted Allenes
Palladium-Catalyzed Three-Component Coupling of 1,1-Dibromoalkenes, Vinylzinc Chloride, and Soft Nucleophiles: One-Pot Synthesis of 1,3-Disubstituted Allenes
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钯催化 1,1-二溴烯烃、乙烯基氯化锌和软亲核试剂的三组分偶联：1,3-二取代丙二烯的一锅法合成
DOI：
10.1021/acsomega.9b03444
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发表时间：
2019
期刊：
影响因子：
4.1
通讯作者：
Ogasawara Masamichi
中科院分区：
文献类型：
--
作者：
Sawano Eri;Ogasawara Masamichi
在钯/Xantphos催化剂存在下，实现了1，1-二溴烯1、乙烯基氯化锌2和碳软亲核试剂3的三组分偶联反应，得到了1，3-二取代联烯产物5，产率高达77%。连续两个钯催化过程，即交叉偶联反应和烯丙基取代，从容易获得的起始化合物中获得。
The three-component coupling reaction of 1,1-dibromoalkenes1, vinylzinc chloride2, and carbon soft nucleophiles3was realized in the presence of the catalytic palladium/Xantphos species, and 1,3-disubstituted allenic products5were obtained in yields of up to 77%. The successive two palladium-catalyzed processes, namely the cross-coupling reaction and the allylic substitution, assembled5from the easily accessible starting compounds.