Mechanisms and pharmacologic control of basophil-derived IL-4 and IL-13.
Mechanisms and pharmacologic control of basophil-derived IL-4 and IL-13.
复制标题
嗜碱性粒细胞衍生的 IL-4 和 IL-13 的机制和药理控制。
DOI：
10.1159/000024036
复制
发表时间：
1999
影响因子：
2.8
通讯作者：
Lichtenstein,LM
中科院分区：
文献类型：
--
作者：
Schroeder,JT;MacGlashanJr,DW;Lichtenstein,LM
Human basophils represent a major source of interleukin (IL) 4 and 13 protein, cytokines which share several biological activities central to the pathogenesis of allergic inflammation. Studies show that the production of these cytokines differs with respect to mode of activation and the time course of their secretion. Pharmacologic evidence indicates that IL–4 generation, which is most prominent with IgE–dependent activation, is mediated through a calcineurin–dependent pathway. In contrast, multiple pathways seem evident in the regulation of IL–13 in basophils.
