Neural circuits subserving the retrieval and maintenance of abstract rules
Neural circuits subserving the retrieval and maintenance of abstract rules
复制标题
DOI：
10.1152/jn.00910.2002
复制
发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Wagner, AD
中科院分区：
文献类型：
--
作者：
Bunge, SA;Kahn, I;Wagner, AD
行为通常受抽象规则或行为指令的约束，这些规则或指令可以从一种上下文中抽象出来并应用于另一种上下文。前额皮质（PFC）被认为对于表示规则很重要，尽管腹外侧（VLPFC）和背外侧（DLPFC）区域的贡献仍然不明确。在本研究中，事件相关的功能磁共振成像被用来检查人类的抽象规则表征。在扫描之前，受试者学会将不熟悉的形状和非单词与特定规则联系起来。在每次功能磁共振成像试验中，这些线索之一的呈现都会有一段延迟，然后是样本和探针刺激。匹配和不匹配规则要求受试者表明样本和探针是否匹配； go规则要求受试者做出不依赖于样本/探针关系的反应。左侧 VLPFC、顶叶皮层和前 SMA 在提示和延迟期间表现出对规则类型的敏感性。当受试者必须维持意外反应（匹配、不匹配）时，这些区域（但不是 DLPFC）的延迟期激活相对于提示信号发出特定反应（进行）时更大。相反，左中颞叶皮层在提示期间表现出规则敏感性，但在延迟期间则没有表现出规则敏感性。这些结果支持这样的假设：VLPFC 与颞叶皮层相互作用以检索与提示相关的语义信息，并与顶叶皮层相互作用以检索和维持跨延迟的相关响应意外事件。未来对跨区域互动的调查将能够对该账户进行全面评估。总的来说，这些结果表明在抽象规则表示过程中招募了多个神经可分离的过程。
Behavior is often governed by abstract rules or instructions for behavior that can be abstracted from one context and applied to another. Prefrontal cortex (PFC) is thought to be important for representing rules, although the contributions of ventrolateral (VLPFC) and dorsolateral (DLPFC) regions remain under-specified. In the present study, event-related fMRI was used to examine abstract rule representation in humans. Prior to scanning, subjects learned to associate unfamiliar shapes and nonwords with particular rules. During each fMRI trial, presentation of one of these cues was followed by a delay and then by sample and probe stimuli. Match and non-match rules required subjects to indicate whether or not the sample and probe matched; go rules required subjects to make a response that was not contingent on the sample/probe relation. Left VLPFC, parietal cortex, and pre-SMA exhibited sensitivity to rule type during the cue and delay periods. Delay-period activation in these regions, but not DLPFC, was greater when subjects had to maintain response contingencies (match, non-match) relative to when the cue signaled a specific response (go). In contrast, left middle temporal cortex exhibited rule sensitivity during the cue but not delay period. These results support the hypothesis that VLPFC interacts with temporal cortex to retrieve semantic information associated with a cue and with parietal cortex to retrieve and maintain relevant response contingencies across delays. Future investigations of cross-regional interactions will enable full assessment of this account. Collectively, these results demonstrate that multiple, neurally separable processes are recruited during abstract rule representation.