Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance.
Flow-Volume Parameters in COPD Related to Extended Measurements of Lung Volume, Diffusion, and Resistance.
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DOI：
10.1155/2013/782052
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发表时间：
2013
影响因子：
4.3
通讯作者：
Tufvesson E
中科院分区：
文献类型：
--
作者：
Jarenbäck L;Ankerst J;Bjermer L;Tufvesson E
根据1秒用力呼气量（FEV 1）和用力肺活量（FVC）将COPD分为不同的GOLD分期，但其价值有限。该研究的目的是将肺功能测定值与COPD患者相比健康吸烟者的肺功能更先进的测量方法相关联。采用流量-容量肺功能测定法、体容积描记法、单次呼气氦稀释法和脉冲肺功能测定法对65例COPD患者和34例健康吸烟者的肺功能进行了检测。所有肺功能参数，测量身体体积描记法，CO扩散，和脉冲多普勒，越来越受到影响，通过增加黄金阶段，但没有相关的FEV 1在任何黄金阶段。相反，它们与FVC%p、FEV 1/FVC和深吸气量的相关性相当好。通过身体体积描记术测量的残余容量（RV）通过GOLD阶段增加，而通过氦气稀释测量的RV减少。这些RV之间的差异提供了有价值的额外信息，并与身体体积描记法和CO扩散测量的大多数其他肺功能参数相关。通过身体体积描记法和脉冲多普勒法测量的气道阻力在COPD分期内相关。不同的肺功能参数在COPD中是重要的，并且彻底的患者表征对于理解疾病是重要的。
Classification of COPD into different GOLD stages is based on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) but has shown to be of limited value. The aim of the study was to relate spirometry values to more advanced measures of lung function in COPD patients compared to healthy smokers. The lung function of 65 COPD patients and 34 healthy smokers was investigated using flow-volume spirometry, body plethysmography, single breath helium dilution with CO-diffusion, and impulse oscillometry. All lung function parameters, measured by body plethysmography, CO-diffusion, and impulse oscillometry, were increasingly affected through increasing GOLD stage but did not correlate with FEV1 within any GOLD stage. In contrast, they correlated fairly well with FVC%p, FEV1/FVC, and inspiratory capacity. Residual volume (RV) measured by body plethysmography increased through GOLD stages, while RV measured by helium dilution decreased. The difference between these RV provided valuable additional information and correlated with most other lung function parameters measured by body plethysmography and CO-diffusion. Airway resistance measured by body plethysmography and impulse oscillometry correlated within COPD stages. Different lung function parameters are of importance in COPD, and a thorough patient characterization is important to understand the disease.