Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish
Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish
复制标题
DOI：
10.1016/j.modgep.2003.12.001
复制
发表时间：
2004-07-01
影响因子：
1.2
通讯作者：
Hibi, M
中科院分区：
文献类型：
--
作者：
Bae, YK;Shimizu, T;Hibi, M
sax 1/nkx1.2和sax 2/nkx1.1是进化上保守的NK-1同源盒基因家族的成员。据报道，SAX 1/NKX1.2在鸡和小鼠的早期和晚期神经发生期间在中枢神经系统中表达，但SAX 2/NKX1.1的表达尚未报道。我们分离了斑马鱼sax 1/nkx1.2和sax 2/nkx1.1的cDNA，并检测了它们的表达。在斑马鱼中，与鸡和小鼠不同，sax 1/nkx1.2从原肠胚中期开始在预期的内侧底板中表达，并且依赖于Nodal信号。从早期分割阶段，sax 1/nkx1.2也表达在后神经外胚层。SAX 2/NKX1.1在预期的眼外肌、位于沿着后连合束的中脑神经元、后脑中的腹侧神经元和脊髓中的中间神经元中表达。(C)2003 Elsevier B. V.保留所有权利。
sax1/nkx1.2 and sax2/nkx1.1 are members of the evolutionally conserved NK-1 homeobox gene family. sax1/nkx1.2 is reported to be expressed in the central nervous system during early and late neurogenesis in the chick and mouse, but the expression of sax2/nkx1.1 has not been reported. We isolated zebrafish cDNAs for sax1/nkx1.2 and sax2/nkx1.1 and examined their expression. In zebrafish, unlike chick and mouse, sax1/nkx1.2 was expressed in the prospective medial floor plate from the mid-gastrula period and was dependent on Nodal signaling. From the early segmentation period, sax1/nkx1.2 was also expressed in the posterior neuroectoderm. sax2/nkx1.1 was expressed in the prospective extraocular muscles, mesencephalic neurons residing along the tract of the posterior commissure, ventral neurons in the hindbrain, and interneurons in the spinal cord. (C) 2003 Elsevier B.V. All rights reserved.