Is 1 Hz rTMS Always Inhibitory in Healthy Individuals?
Is 1 Hz rTMS Always Inhibitory in Healthy Individuals?
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DOI：
10.2174/1874440001206010069
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Henn F
中科院分区：
文献类型：
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作者：
Caparelli E;Backus W;Telang F;Wang G;Maloney T;Goldstein R;Henn F
1 Hz重复经颅磁刺激（rTMS）被认为对健康人有抑制作用，因为它抑制了运动或视觉皮层的兴奋性，分别表示为运动或光幻视阈值（PT）的增加。然而，rTMS作用的潜在机制和脑结构仍不清楚。在这项研究中，我们使用了两个会议的同时TMS功能磁共振成像（fMRI），一个之前和一个之后，15分钟的1Hz rTMS映射与减少皮质兴奋性的初级视觉皮层的1 Hz rTMS诱导的脑功能的变化，当TMS应用于健康志愿者的枕区。两组人被评估，一组人可以看到光幻视，另一组人缺乏这种感知。在第一组中，通过PT的增加观察到由1 Hz rTMS诱导的抑制作用，但并未导致脑激活的整体减少，相反，在rTMS前后显示激活模式的变化。相反，对于第二组，仅在少数大脑区域观察到大脑激活的变化，这表明1 Hz rTMS的作用可能并不对每个人都具有抑制作用，并且rTMS的抑制/兴奋作用的概念可能需要修改。
1 Hz repetitive Transcranial Magnetic Stimulation (rTMS) is considered to have an inhibitory effect in healthy people because it suppresses the excitability of the motor or visual cortex that is expressed as an increase in the motor or the phosphene threshold (PT), respectively. However, the underlying mechanisms and the brain structures involved in the action of rTMS are still unknown. In this study we used two sessions of simultaneous TMS-functional magnetic resonance imaging (fMRI), one before and one after, 15 minutes of 1Hz rTMS to map changes in brain function associated with the reduction in cortical excitability of the primary visual cortex induced by 1 Hz rTMS, when TMS was applied on the occipital area of healthy volunteers. Two groups were evaluated, one group composed of people that can see phosphenes, and another of those lacking this perception. The inhibitory effect, induced by the 1 Hz rTMS, was observed through the increase of the PT, in the first group, but did not lead to a global reduction in brain activation, instead, showed change in the activation pattern before and after rTMS. Conversely, for the second group, changes in brain activation were observed just in few brain areas, suggesting that the effect of 1 Hz rTMS might not be inhibitory for everyone and that the concept of inhibitory/excitatory effect of rTMS may need to be revised.