Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders Findings from the Netherlands Study of Depression and Anxiety (NESDA)
Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders Findings from the Netherlands Study of Depression and Anxiety (NESDA)
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DOI：
10.1016/j.jad.2010.12.014
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发表时间：
2011-06-01
影响因子：
6.6
通讯作者：
Penninx, Brenda W. J. H.
中科院分区：
文献类型：
--
作者：
Boschloo, Lynn;Vogelzangs, Nicole;Penninx, Brenda W. J. H.
简介：本研究探讨了酒精滥用和酒精依赖的共病性以及焦虑和/或抑郁人群中的风险指标，还考虑了疾病的时间顺序。方法：基线数据来自荷兰抑郁和焦虑研究（NESDA），包括2329名终生DSM-IV焦虑患者（社交恐怖症、广泛性焦虑症、惊恐障碍和广场恐怖症）和/或抑郁症（重性抑郁症和心境恶劣）障碍和652名对照。建立了DSM-IV酒精滥用和依赖的终身诊断，以及有关社会人口统计学，脆弱性，成瘾相关和焦虑/抑郁相关特征的信息。使用发病年龄回顾性地建立了疾病的时间顺序。结果：在患有焦虑/抑郁综合症的人中，20.3%的人表现出酒精依赖，而对照组的这一比例为5.5%。各组之间的酗酒患病率相似（+/- 12%）。焦虑和/或抑郁人群酒精依赖的独立风险指标为男性、脆弱性因素（酒精依赖家族史、焦虑/抑郁家族史、经验开放性、低风险、单身和童年创伤）、成瘾相关因素（吸烟和非法药物使用）和早期焦虑/抑郁发作。二级酒精依赖的人更神经质，更经常是单一和孤独的，而与初级酒精依赖的人更经常是男性和更extruter.Discussion：酒精依赖，但不滥用，是更普遍的焦虑和/或抑郁的人。患有酒精依赖共病的人构成了一个独特的亚组焦虑和/或抑郁的人，其特征是成瘾相关的习惯和脆弱性。然而，存在相当大的变化，取决于时间顺序的障碍的特征。这方面的知识可能会提高识别和治疗那些焦虑和/或抑郁的患者谁是额外患有酒精依赖。(C)2010爱思唯尔有限公司版权所有。
Introduction: This study examines comorbidity of alcohol abuse and alcohol dependence as well as its risk indicators among anxious and/or depressed persons, also considering temporal sequencing of disorders.Methods: Baseline data from the Netherlands Study of Depression and Anxiety (NESDA) were used, including 2329 persons with lifetime DSM-IV anxiety (social phobia, generalized anxiety disorder, panic disorder, and agoraphobia) and/or depressive (major depressive disorder and dysthymia) disorders and 652 controls. Lifetime diagnoses of DSM-IV alcohol abuse and dependence were established, as well as information about socio-demographic, vulnerability, addiction-related and anxiety/depression-related characteristics. Temporal sequencing of disorders was established retrospectively, using age of onset.Results: Of persons with combined anxiety/depression 20.3% showed alcohol dependence versus 5.5% of controls. Prevalence of alcohol abuse was similar across groups (+/- 12%). Independent risk indicators for alcohol dependence among anxious and/or depressed persons were male gender, vulnerability factors (family history of alcohol dependence, family history of anxiety/depression, openness to experience, low conscientiousness, being single, and childhood trauma), addiction-related factors (smoking and illicit drug use) and early anxiety/depression onset. Persons with secondary alcohol dependence were more neurotic, more often single and lonelier, while persons with primary alcohol dependence were more often male and more extravert.Discussion: Alcohol dependence, but not abuse, is more prevalent in anxious and/or depressed persons. Persons with comorbid alcohol dependence constitute a distinct subgroup of anxious and/or depressed persons, characterized by addiction-related habits and vulnerability. However, considerable variation in characteristics exists depending on temporal sequencing of disorders. This knowledge may improve identification and treatment of those anxious and/or depressed patients who are additionally suffering from alcohol dependence. (C) 2010 Elsevier B.V. All rights reserved.