The immune risk phenotype is associated with IL-6 in the terminal decline stage:: Findings from the Swedish NONA immune longitudinal study of very late life functioning
The immune risk phenotype is associated with IL-6 in the terminal decline stage:: Findings from the Swedish NONA immune longitudinal study of very late life functioning
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DOI：
10.1016/j.mad.2006.04.003
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发表时间：
2006-08-01
影响因子：
5.3
通讯作者：
Johansson, Boo
中科院分区：
文献类型：
--
作者：
Wikby, Anders;Nilsson, Bengt-Olof;Johansson, Boo
在目前的NONA免疫纵向研究中，我们进一步检查了先前确定的T细胞免疫风险表型（IRP），相对炎症活性，发病率和> 90岁的高龄个体的2年死亡率。对T细胞亚群以及炎症标志物IL-6、IL-10、C反应蛋白、甲状腺素运载蛋白和白蛋白进行了评价。IRP和低度炎症预测了57%的观察到的死亡和97%的生存超过2年，并没有显着影响个人的健康状况，这表明T细胞免疫衰老和低度炎症的生理老化过程是最重要的晚年生存。IRP非幸存者在基线时仅表现出轻微的炎症活动，但与幸存者相比，在随访时活动增加。结果表明IRP个体的一系列阶段，开始是在早期生活中获得CMV感染，随后产生CD 8 + CD 28-细胞以控制持续的CMV感染，并最终发展为IRP。有趣的是，我们还发现罕见的个体通过免疫抑制过程而脱离IRP类别，包括IL-6和IL-10的增加以及CD 3 + CD 8 + CD 28-细胞数量的减少。这些特殊个体的进一步表征可能会让我们深入了解那些直到死亡仍处于IRP类别的人的补救方法。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
In the present NONA immune longitudinal study, we further examine the previously identified T cell immune risk phenotype (IRP), relative inflammatory activity, morbidity and 2-year mortality in very old individuals > 90 years. T-cell subsets as well as the inflammatory markers IL-6, IL-10, C-reactive protein, transthyretin and albumin were evaluated. IRP and low-grade inflammation predicted 57% of observed deaths and 97% of survival over 2 years, and was not significantly affected by individuals' health status, suggesting that the physiological ageing processes of T-cell immunosenescence and low-grade inflammation are of primary importance in late life survival. IRP non-survivors showed only a minor inflammatory activity at baseline, but had in contrast to survivors developed increased activity at follow-up. The results suggest a sequence of stages for IRP individuals that begin with acquisition of CMV infection in earlier life, followed by generation of CD8+CD28- cells to control persistent CMV infection and eventually the development of an IRP Intriguingly, we also found that rare individuals moved out of the IRP category by a process of immune suppression, including increases in IL-6 and IL-10 and decreases in the number of CD3+CD8+CD28- cells. The further characterisation of these exceptional individuals may allow insight into remedial approaches for those who remain in the IRP category until death. (c) 2006 Elsevier Ireland Ltd. All rights reserved.