Role of fibrinolytic parameters and plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism on premature atherosclerosis in SLE patients
Role of fibrinolytic parameters and plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism on premature atherosclerosis in SLE patients
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DOI：
10.1177/0961203311404911
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发表时间：
2011-10-01
期刊：
影响因子：
2.6
通讯作者：
Yavuz, S.
中科院分区：
文献类型：
--
作者：
Bicakcigil, M.;Tasan, D. A.;Yavuz, S.
早发性动脉粥样硬化已被认为是系统性红斑狼疮（SLE）的主要共病状态。本研究旨在探讨组织型纤溶酶原激活物（tPA）和纤溶酶原激活物抑制物（派-1）抗原浓度及派-1基因4G/5G多态性对SLE患者动脉粥样硬化发生的影响。对106例SLE患者、28例大动脉炎（TA）患者和98例健康对照者（HC）进行了研究。ELISA法检测派-1和tPA抗原水平。采用等位基因特异性PCR方法检测派-1基因多态性。SLE患者的斑块发生率（22.6%）（p=0.01）和IMT（p=0.04）分别显著高于HC。在多变量回归分析中，只有发病年龄与斑块形成相关（p=0.001）。SLE患者的血浆tPA ag水平显著高于HC（p=0.005），派-1 ag水平显著高于TA患者（p=0.03）。派-1基因的基因型分布和等位基因频率在两组间均无显著性差异，但4G/4G基因型SLE患者的IMT（p=0.02）钙评分显著高于4G 5G/5G 5G基因型SLE患者（p=0.006）。目前的研究表明，在预测冠状动脉疾病（CAD）方面，测量纤溶参数除了传统和新的危险因素外几乎没有额外的益处。Lupus（2011）20，1063-1071.
Premature atherosclerosis has been recognized as a major co-morbid condition in systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of tPA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor) antigen concentrations and 4G/5G polymorphism of the PAI-1 gene on the development of atherosclerosis in SLE patients. One hundred and six SLE patients, 28 Takayasu arteritis (TA) patients and 98 healthy control subjects (HCs) were studied. PAI-1 and tPA antigen levels were measured by ELISA method. PAI-1 gene polymorphism was determined by using allele-specific PCR method. SLE patients had a significantly higher frequency (22.6%) of plaque (p=0.01) and higher IMT (p=0.04) compared with HCs respectively. Only age at disease onset was associated with plaque formation in multivariate regression analysis (p=0.001). Plasma tPA ag levels in SLE patients were significantly higher compared with HCs (p=0.005) and PAI-1 ag levels were significantly higher compared with TA patients (p=0.03). There were no significant differences between study groups in both genotype distribution and allele frequencies of PAI-1 gene, but SLE patients with 4G/4G genotype had higher IMT (p=0.02) calcium scoring (p=0.006) compared with 4G5G/5G5G genotypes. The present study suggests that measuring fibrinolytic parameters would have little additional benefit beyond traditional and novel risk factors in predicting coronary artery disease (CAD). Lupus (2011) 20, 1063-1071.