The cytokine profile of women with severe anxiety and depression during pregnancy
The cytokine profile of women with severe anxiety and depression during pregnancy
复制标题
DOI：
10.1186/s12888-019-2087-6
复制
发表时间：
2019-04-03
期刊：
影响因子：
4.4
通讯作者：
Camacho-Arroyo, I.
中科院分区：
文献类型：
--
作者：
Leff Gelman, P.;Mancilla-Herrera, I.;Camacho-Arroyo, I.
背景：关于促炎症细胞因子与抑郁症之间关系的有争议的研究结果在怀孕受试者中已有报道。关于焦虑及其与细胞因子的关系的数据在孕妇中是稀缺的。为了解妊娠期焦虑与细胞因子之间的关系，本研究采用汉密尔顿抑郁量表(HDRS)和汉密尔顿焦虑量表(HARS)对139例妊娠晚期出现重度抑郁(SD)和严重焦虑(SA)的孕妇和40例无抑郁和焦虑的对照组进行评定。血清细胞因子的测定采用多重微珠法。采用相关性检验进行数据分析，并进行组间比较。结果：SD+SA患者外周血中Th1-(IL-6、TNF-、IL-2、IFN-)、Th17-(IL-17A、IL-22)和Th2-(IL-9、IL-10、IL-13)相关细胞因子水平最高。SA组Th1-(IL-6、TNF-、IL-2、IFN-)和Th2-(IL-4、IL-10)相关细胞因子水平明显高于对照组。SA组HDRS与IL-2、IL-6、TNF-α呈正相关(P<0.05)。
Background: Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are available in pregnant women. To understand the association between anxiety and cytokines during pregnancy, we conducted the present study in women with or without depression.Methods: Women exhibiting severe depression (SD) and severe anxiety (SA) during the 3rd trimester of pregnancy (n=139) and control subjects exhibiting neither depression nor anxiety (n=40) were assessed through the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Serum cytokines were measured by a multiplex bead-based assay. Correlation tests were used to analyze the data and comparisons between groups were performed. A general linear model of analysis of variance was constructed using the group as a dependent variable, interleukin concentrations as independent variables, and HDRS/HARS scores and gestational weeks as covariables.Results: The highest levels of Th1- (IL-6, TNF-, IL-2, IFN-), Th17- (IL-17A, IL-22), and Th2- (IL-9, IL-10, and IL-13) related cytokines were observed in women with SD+SA. The SA group showed higher concentrations of Th1- (IL-6, TNF-, IL-2, IFN-) and Th2- (IL-4, and IL-10) related cytokines than the controls. Positive correlations were found between HDRS and IL-2, IL-6, and TNF- in the SA group (p