Subcutaneous drug delivery and the role of the lymphatics.
Subcutaneous drug delivery and the role of the lymphatics.
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DOI：
10.1016/j.ddtec.2005.05.006
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Charman, Susan A
中科院分区：
文献类型：
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作者：
McLennan, Danielle N;Porter, Christopher J H;Charman, Susan A
皮下注射被广泛用作具有有限口服生物利用度的化合物的递送途径或用作改变或延长释放曲线的手段。在这篇评论中，影响从皮下空间吸收的因素进行了讨论，特别强调差异药物吸收到底层的血液或毛细淋巴管。制剂和有针对性的交付方法，利用皮下给药途径，审查参考相关技术和未来的挑战。
Subcutaneous injections are widely utilised as a delivery route for compounds with limited oral bioavailability or as a means to modify or extend the release profile. In this review, factors affecting absorption from the subcutaneous space are discussed with particular emphasis on differential drug absorption into either the underlying blood or lymphatic capillaries. Formulation and targeted delivery approaches, which utilise the subcutaneous administration route, are reviewed with reference to associated technologies and future challenges.: