Optimization of Coronary Attenuation in Coronary Computed Tomography Angiography Using Diluted Contrast Material
Optimization of Coronary Attenuation in Coronary Computed Tomography Angiography Using Diluted Contrast Material
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DOI：
10.1253/circj.cj-13-1101
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Mochizuki, Teruhito
中科院分区：
文献类型：
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作者：
Kawaguchi, Naoto;Kurata, Akira;Mochizuki, Teruhito
背景：本研究的目的是评估用于冠状动脉计算机断层扫描血管造影 (CTA) 的稀释造影剂 (CM) 的个性化方案。方法和结果：100 名疑似冠状动脉疾病的患者在 256 排多排 CT 扫描仪上接受了回顾性心电图门控冠状动脉 CTA。在稀释 CM 方案 (n=50) 中，最佳扫描时机和 CM 稀释率由定时推注扫描确定，20% CM 稀释（10 秒内 5 ml/s）被认为适合实现 350 Hounsfield 单位 (HU) 的目标动脉衰减。在体重 (BW) 调整方案（n=50, 222 mg 碘/kg）中，仅通过定时推注扫描确定最佳扫描时机。两种方案之间的定时推注扫描和实际扫描中的注射速率和体积是相同的。我们比较了两种方案之间冠状动脉衰减的平均值和变化。稀释的 CM 和 BW 调整方案中的冠状动脉衰减（平均值 +/- SD）分别为 346.1 +/- 23.9 HU 和 298.8 +/- 45.2 HU。与 BW 调整方案相比，稀释的 CM 方案提供了显着更高的冠状动脉衰减和更低的方差（P
Background: The purpose of this study was to evaluate a personalized protocol with diluted contrast material (CM) for coronary computed tomography angiography (CTA).Methods and Results: One hundred patients with suspected coronary artery disease underwent retrospective electrocardiogram-gated coronary CTA on a 256-slice multidetector-row CT scanner. In the diluted CM protocol (n=50), the optimal scan timing and CM dilution rate were determined by the timing bolus scan, with 20% CM dilution (5 ml/s during 10s) being considered suitable to achieve the target arterial attenuation of 350 Hounsfield units (HU). In the body weight (BW)-adjusted protocol (n=50, 222 mg iodine/kg), only the optimal scan timing was determined by the timing bolus scan. The injection rate and volume in the timing bolus scan and real scan were identical between the 2 protocols. We compared the means and variations in coronary attenuation between the 2 protocols. Coronary attenuation (mean +/- SD) in the diluted CM and BW-adjusted protocols was 346.1 +/- 23.9 HU and 298.8 +/- 45.2 HU, respectively. The diluted CM protocol provided significantly higher coronary attenuation and lower variance than did the BW-adjusted protocol (P