Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
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DOI：
10.1016/s0092-8674(00)80185-3
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发表时间：
1997-04-04
期刊：
影响因子：
64.5
通讯作者：
Kunau, WH
中科院分区：
文献类型：
--
作者：
Albertini, M;Rehling, P;Kunau, WH
Pex14p是酿酒酵母（S. cerevisiae）的一种过氧化物酶体蛋白，它附着在过氧化物酶体膜的外表面，是蛋白质输入机制的一个组成部分。Pex14p与过氧化物酶体靶向信号1（PTS1）受体和过氧化物酶体靶向信号2（PTS2）受体都相互作用。它是已知唯一能与PTS2受体结合的过氧化物酶体膜蛋白，因此可能介导PTS2依赖性蛋白质输入的膜对接过程。这些结果表明，这两种输入途径存在重叠，而且Pex14p代表了汇聚点。Pex14p还与另外两种膜结合的过氧化物酶体蛋白相互作用，包括Pex13p，它是PTS1受体的另一种结合蛋白。这里给出的数据与过氧化物酶体膜中两种过氧化物酶体靶向信号依赖性蛋白质输入途径存在共同转运机制的观点是一致的。
Pex14p, an S. cerevisiae peroxin, is attached to the outer face of the peroxisomal membrane and is a component of the protein import machinery. Pex14p interacts with both the PTS1 and PTS2 receptors. It is the only known peroxisomal membrane protein that binds the PTS2 receptor and might thus mediate the membrane docking event of PTS2-dependent protein import. These results suggest that the two import pathways overlap and, furthermore, that Pex14p represents the point of convergence. Pex14p also interacts with two other membrane-bound peroxins including Pex13p, another binding protein for the PTS1 receptor. The data presented here are consistent with the idea of a common translocation machinery for both PTS-dependent protein import pathways in the peroxisomal membrane.