The Animal Naming Test: An Easy Tool for the Assessment of Hepatic Encephalopathy
The Animal Naming Test: An Easy Tool for the Assessment of Hepatic Encephalopathy
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DOI：
10.1002/hep.29146
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发表时间：
2017-07-01
期刊：
影响因子：
13.5
通讯作者：
Amodio, Piero
中科院分区：
文献类型：
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作者：
Campagna, Francesca;Montagnese, Sara;Amodio, Piero
筛查不会导致明显定向障碍或星状突起的肝性脑病(轻度肝性脑病[MHE]/1级肝性脑病)很重要。我们检查了动物命名测试(ANT(1))(1分钟内列出的最大动物数量)在这种情况下是否有用。总共有208名健康对照、40名炎症性肠病对照和327名连续的肝硬变患者接受了ANT(1)。采用心理测量HE评分对患者进行MHE检查，对146例患者进行脑电地形图评估，对202例患者进行随访，观察临床HE的发生情况及死亡情况。在健康对照组中，ANT(1)受教育程度有限(80岁，P<；0.001)的影响。通过年龄和教育程度的调整，得到了简化的蚂蚁(1)(S-蚂蚁(1))。S-蚂蚁(1)=2级，126例为MHE/1级HE。本组患者的S-ANT(1)低于未受损患者(12+/-0.4vs16+/-0.70，P<0.001)，高于HE>；=2级患者(4+/-0.9)。高血压病患者1级的S-蚂蚁(1)明显低于男性高血压病患者。根据受试者操作特征分析(Youden‘s index)，15只动物对未受损和MHE/1级HE患者的辨别能力最好。因此，三个级别的分数(S-蚂蚁(1)=15，10为1
Screening for hepatic encephalopathy (HE) that does not cause obvious disorientation or asterixis (minimal HE [MHE]/grade 1 HE) is important. We examined if the animal naming test (ANT(1)) (maximum number of animals listed in 1 minute) is useful in this context. In total, 208 healthy controls, 40 controls with inflammatory bowel disease, and 327 consecutive patients with cirrhosis underwent the ANT(1). Patients were tested for MHE by the psychometric HE score, and 146 were assessed by electroencephalography; 202 patients were followed up regarding the occurrence of overt HE and death. In the healthy controls, ANT(1) was influenced by limited education (80 years, P < 0.001). Using an age and education adjusting procedure, the simplified ANT(1) (S-ANT(1)) was obtained. An S-ANT(1) of = grade 2, and 126 as having MHE/grade 1 HE. This group had lower S-ANT(1) than unimpaired patients (12 +/- 0.4 versus 16 +/- 0.7, P < 0.001) and higher S-ANT(1) than those with HE >= grade 2 (4 +/- 0.9). In grade 1 HE the S-ANT(1) was lower than in MHE. Following receiver operating characteristic analysis (Youden's index), 15 animals produced the best discrimination between unimpaired and MHE/grade 1 HE patients. Thus, a three-level score (0 for S-ANT(1) >= 15, 1 for 10