Oxygen and inulin transport measurements in a planar tissue-engineered bioartificial organ.
Oxygen and inulin transport measurements in a planar tissue-engineered bioartificial organ.
复制标题
平面组织工程生物人工器官中的氧气和菊粉传输测量。
作者：
Z. Ding;R. Fournier
在体内氧和菊粉运输率测定在平面组织工程生物人工器官植入大鼠。一个房室模型被用来描述运输的细胞室之间的氧气和菊粉，通过免疫隔离膜，并在邻近免疫隔离膜的新生血管化区域。对血浆菊糖水平和进入装置的氧气输送速率进行非线性回归分析，提供了有关生物人工器官附近区域血管化程度的信息。从体内转运数据分析中获得的关键参数包括平均毛细血管血氧分压、Krogh组织圆柱半径、细胞外体积分数和毛细血管血液停留时间。这四个参数是评估生物人工器官中免疫隔离膜附近组织血管化程度的重要指标。本文报道的氧和菊粉转运技术是描述生物人工器官体内转运特性和评估组织工程结构内血管化的有用工具。
In vivo oxygen and inulin transport rates were measured in a planar tissue-engineered bioartificial organ implanted in a rat. A compartmental model was used to describe the transport of oxygen and inulin between the cell chamber, across the immunoisolation membrane, and within the neovascularized region adjacent to the immunoisolation membrane. A nonlinear regression analysis of the plasma inulin levels and the oxygen transport rate into the device provided information on the degree of vascularization in the region adjacent to the bioartificial organ. Key parameters that were obtained from the analysis of the in vivo transport data included the average capillary blood oxygen partial pressure, the Krogh tissue cylinder radius, the extracellular volume fraction, and the capillary blood residence time. These four parameters are important indicators for assessing the degree of vascularization in the tissue adjacent to the immunoisolation membrane in the bioartificial organ. The oxygen and inulin transport technique reported here is a useful tool for describing the in vivo transport characteristics of a bioartificial organ and for assessment of the vascularization within tissue engineered structures.
肝素结合生长因子 1 诱导体内类器官新生血管结构的形成。
DOI：
10.1073/pnas.86.20.7928
发表时间：
1989
影响因子：
11.1
作者：
Thompson,JA;Haudenschild,CC;Anderson,KD;DiPietro,JM;Anderson,WF;Maciag,T
通讯作者：
Maciag,T
免疫屏障装置中移植的胰岛的数量和体积。
影响因子：
3.3
作者：
Suzuki,K;Bonner-Weir,S;Hollister-Lock,J;Colton,CK;Weir,GC
通讯作者：
Weir,GC