Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
复制标题
DOI：
10.1111/j.1558-5646.2007.00151.x
复制
发表时间：
2007-08-01
期刊：
影响因子：
3.3
通讯作者：
Kawecki, Tadeusz J.
中科院分区：
文献类型：
--
作者：
Flatt, Thomas;Kawecki, Tadeusz J.
繁殖和寿命之间的权衡无处不在，但对其潜在机制知之甚少。在这里，我们将保幼激素类似物（JHa）甲氧普林的治疗和果蝇的实验进化结合起来，研究保幼激素（JH）在生理和进化水平上介导这种权衡的潜在作用。在幼虫培养基中暴露于 JHa（以及羽化后长达 24 小时）会增加早期生命的繁殖力，但会缩短正常（未选择的）果蝇的寿命，这支持了 JH 在调节权衡中的生理作用。对于之前在含有 JHa 的培养基上培育了 19 代的蝇系来说，这种影响对于寿命而言要小得多，并且对于繁殖力来说也检测不到。此外，即使在没有 JHa 处理的情况下，这些选择系也比未选择的对照寿命更长，并且早期繁殖力没有明显降低。因此，对 JHa 抗性的选择显然诱导了 JH 代谢或信号传导的一些进化变化，作为相关反应导致了更长的寿命。这支持了 JH 可能介导更长寿命进化的假设，但与我们的预期相反，这显然不需要与繁殖力进行权衡。
Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa) methoprene and experimental evolution in Drosophila melanogaster to study the potential role of juvenile hormone (JH) in mediating such trade-offs at both the physiological and evolutionary level. Exposure to JHa in the larval medium (and up to 24 h posteclosion) increased early life fecundity but reduced life span of normal (unselected) flies, supporting the physiological role of JH in mediating the trade-off. This effect was much smaller for life span, and not detectable for fecundity, in fly lines previously bred for 19 generations on a medium containing JHa. Furthermore, these selection lines lived longer than unselected controls even in the absence of JHa treatment, without a detectable reduction in early life fecundity. Thus, selection for resistance to JHa apparently induced some evolutionary changes in JH metabolism or signaling, which led to longer life span as a correlated response. This supports the hypothesis that JH may mediate evolution of longer life span, but-contrary to our expectation-this apparently does not need to trade-off with fecundity.