Fecal mutagens in two Japanese populations with different colon cancer risks.
Fecal mutagens in two Japanese populations with different colon cancer risks.
复制标题
具有不同结肠癌风险的两个日本人群中的粪便诱变剂。
作者：
H. Mower;D. Ichinotsubo;L. W. Wang;M. Mandel;G. Stemmermann;A. Nomura;L. Heilbrun;S. Kamiyama;A. Shimada
来自夏威夷223名结肠癌高危日本人的粪便和来自日本北部农村低结肠癌风险的166名日本人的粪便，在五个不同的测试条件下被证明含有突变活性。第一种试验使用Ames TA98和TA100沙门氏菌试验，在存在和不存在大鼠肝微粒体的情况下检测乙醚可溶性诱变剂。其中，TA98直接作用突变物在高危人群的粪便中的出现频率高于低危人群，具有高度统计学意义(p<0.01)。在夏威夷的日本人的粪便中，由大鼠肝微粒体激活的TA98诱变剂的出现频率也明显更高(p<0.05)。TA100在存在和不存在大鼠肝微粒体的情况下检测到的诱变剂在这两个日本人中都不常见。用于检测粪便诱变物的第二个细菌测试系统使用的是大肠杆菌rec-。该系统检测水溶性粪便诱变物，这种诱变物在高危人群中也比在低危人群中出现得更频繁(p<0.05)。
Human feces from 223 Japanese in Hawaii at high risk for colon cancer and feces from 166 Japanese of northern rural Japan at low risk for colon cancer were shown to contain mutagenic activity under five different test conditions. The first assay, using the Ames TA98 and TA100 Salmonella test, detected ether-soluble mutagens in the presence and absence of rat liver microsomes. Of these, the TA98 direct-acting mutagens are present more frequently in the feces of the high-risk population than the low-risk population at a high level of statistical significance (p less than 0.01). TA98 mutagens activated by rat liver microsomes also occur significantly more frequently in the feces of the Japanese from Hawaii (p less than 0.05). Mutagens detected by TA100 in the presence and absence of rat liver microsomes are not commonly found in either Japanese population. The second bacterial test system used to detect fecal mutagens uses Escherichia coli rec-. This system detects water-soluble fecal mutagens which are also present more frequently in the high-risk population than in the low-risk population (p less than 0.05).
DOI：
10.1016/0027-5107(80)90122-0
发表时间：
1980
期刊：
Mutation research
影响因子：
--
作者：
Reddy,BS;Sharma,C;Darby,L;Laakso,K;Wynder,EL
通讯作者：
Wynder,EL
影响因子：
9.7
作者：
Wang,YY;Vuolo,LL;Spingarn,NE;Weisburger,JH
通讯作者：
Weisburger,JH