Choline metabolism and risk of breast cancer in a population-based study
Choline metabolism and risk of breast cancer in a population-based study
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DOI：
10.1096/fj.07-101279
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发表时间：
2008-06-01
期刊：
影响因子：
4.8
通讯作者：
Chen, Jia
中科院分区：
文献类型：
--
作者：
Xu, Xinran;Gammon, Marilie D.;Chen, Jia
胆碱是甲基代谢所必需的营养物质，但其在癌变和肿瘤进展中的作用尚不清楚。通过对1508例病例和1556例对照的人群研究，我们调查了饮食中胆碱和两种相关微量营养素（蛋氨酸和甜菜碱）的摄入与乳腺癌风险的关系。胆碱摄入量最高的五分位数与较低的乳腺癌风险相关[优势比（OR）： 0.76；95%置信区间（CI）： 0.58-1.00]与最低五分位数相比。两种推测功能的胆碱代谢基因ppt -774G > C （rs12325817）和CHDH +432G > T （rs12676）也被发现与乳腺癌风险相关。与ppt GG基因型相比，CC基因型变异与乳腺癌风险增加相关（OR: 1.30; 95% CI: 1.01-1.67）。与主要的G等位基因相比，CHDH次要T等位基因也与增加的风险相关（OR: 1.19; 95% CI: 1.00-1.41）。BHMT rs3733890多态性也被检测，但发现与乳腺癌风险无关。我们观察到膳食甜菜碱摄入量与ppt rs7926多态性之间存在显著的交互作用（P-interaction = 0.04）。我们的研究结果表明，胆碱代谢可能在乳腺癌病因学中起重要作用。
Choline is an essential nutrient required for methyl group metabolism, but its role in carcinogenesis and tumor progression is not well understood. By utilizing a population-based study of 1508 cases and 1556 controls, we investigated the associations of dietary intake of choline and two related micronutrients, methionine and betaine, and risk of breast cancer. The highest quintile of choline consumption was associated with a lower risk of breast cancer [odds ratio (OR): 0.76; 95% confidence interval (CI): 0.58-1.00] compared with the lowest quintile. Two putatively functional single nucleotide polymorphisms of choline-metabolizing genes, PEMT -774G > C (rs12325817) and CHDH +432G > T (rs12676), were also found be related to breast cancer risk. Compared with the PEMT GG genotype, the variant CC genotype was associated with an increased risk of breast cancer (OR: 1.30; 95% CI: 1.01-1.67). The CHDH minor T allele was also associated with an increased risk (OR: 1.19; 95% CI: 1.00-1.41) compared with the major G allele. The BHMT rs3733890 polymorphism was also examined but was found not to be associated with breast cancer risk. We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P-interaction = 0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology.